FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases

Wei Shen; Modan Yang; Hao Chen; Chiyu He; Huigang Li; Xinyu Yang; Jianyong Zhuo; Zuyuan Lin; Zhihang Hu; Di Lu; Xiao Xu

doi:10.1016/j.gendis.2023.05.019

Genes & Diseases 2024, 11(3): 101027 https://doi.org/10.1016/j.gendis.2023.05.019

Review Article |

Open Access | Issue | Published: 13 July 2023

FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases

Show Author's Information Hide Author's Information Wei Shen^{^a^,^b^,^c^,^d^,^,¹}, Modan Yang^{^a^,^b^,^c^,^d^,¹}, Hao Chen^{^a^,^b^,^c^,^d^,¹}, Chiyu He^{^a^,^b^,^c^,^d}, Huigang Li^{^a^,^b^,^c^,^d}, Xinyu Yang^{^a^,^b^,^c^,^d}, Jianyong Zhuo^{^a^,^b^,^c^,^d}, Zuyuan Lin^{^a^,^b^,^c^,^d}, Zhihang Hu^{^a^,^b^,^c^,^d}, Di Lu^{^a^,^b^,^c^,^d}(

), Xiao Xu^{^a^,^c^,^d^,^e}

(

)

Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China

Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China

The Institute for Organ Repair and Regenerative Medicine of Hangzhou, Hangzhou, Zhejiang 310006, China

Institute of Organ Transplantation, Zhejiang University, Hangzhou, Zhejiang 310003, China

National Center for Healthcare Quality Management in Liver Transplant, Hangzhou, Zhejiang 310003, China

Peer review under responsibility of Chongqing Medical University.

¹ These authors contributed equally to this work.

Keywords:

Stress, Autophagy, mTOR, Liver diseases, Fibroblast growth factor 21

Cite this article:

Shen W, Yang M, Chen H, et al. FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases. Genes & Diseases, 2024, 11(3): 101027. https://doi.org/10.1016/j.gendis.2023.05.019

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Abstract About this article

Abstract

Liver diseases are worldwide problems closely associated with various stresses, such as endoplasmic reticulum stress. The exact interplay between stress and liver diseases remains unclear. Autophagy plays an essential role in maintaining homeostasis, and recent studies indicate tight crosstalk between stress and autophagy in liver diseases. Once the balance between damage and autophagy is broken, autophagy can no longer resist injury or maintain homeostasis. In recent years, FGF21 (fibroblast growth factor 21)-induced autophagy has attracted much attention. FGF21 is regarded as a stress hormone and can be up-regulated by an abundance of signaling pathways in response to stress. Also, increased FGF21 activates autophagy by a complicated signaling network in which mTOR plays a pivotal role. This review summarizes the mechanism of FGF21-mediated autophagy and its derived application in the defense of stress in liver diseases and offers a glimpse into its promising prospect in future clinical practice.

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Publication history

Received: 24 February 2023

Revised: 23 April 2023

Accepted: 09 May 2023

Published: 13 July 2023

Issue date: May 2024

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Acknowledgements

We thank all members of the Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province for their helpful suggestions regarding the manuscript. The figures in our review were created with BioRender.com.

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).