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Rapid Communication | Open Access

Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma

Yuyuan Zhanga,1, Ziyang Zud,1, Hui Xua,b,c,1, Siyuan Wenga, Yuqing Rene, Quan Chengf, Peng Luog, Jian Zhangg, Zaoqu Liua,b,c( ), Xinwei Hana,b,c( )
Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Interventional Institute of Zhengzhou University, Zhengzhou, Henan 450052, China
Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan 450052, China
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China

Peer review under responsibility of Chongqing Medical University.

1These authors contributed equally to this work and shared the first authorship.

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Genes & Diseases
Volume 11 Issue 3,
May 2024
Article number: 100993
DOI: 10.1016/j.gendis.2023.05.006

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Cite this article:
Zhang Y, Zu Z, Xu H, et al. Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma. Genes & Diseases, 2024, 11(3): 100993. https://doi.org/10.1016/j.gendis.2023.05.006

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Received: 05 February 2023
Published: 29 June 2023
© 2023 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).