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Review Article | Open Access

Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases

Taiyu Shanga,1, Tianyi Jiangb,c,1, Xiaowen Cuib, Yufei Panb, Xiaofan Fengb,c, Liwei Dongb,c( ), Hongyang Wanga,b,c,d ( )
School of Life Sciences, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China
National Center for Liver Cancer, The Naval Medical University, Shanghai 201805, China
International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai 200438, China
Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Second Military Medical University & Ministry of Education, Shanghai 200438, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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Abstract

The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative capacities. The hepatobiliary system originates from the foregut endoderm, in which cells undergo multiple events of cell proliferation, migration, and differentiation to form the liver parenchyma and ductal system under the hierarchical regulation of transcription factors. Studies on liver development and diseases have revealed that SRY-related high-mobility group box 9 (SOX9) plays an important role in liver embryogenesis and the progression of hepatobiliary diseases. SOX9 is not only a master regulator of cell fate determination and tissue morphogenesis, but also regulates various biological features of cancer, including cancer stemness, invasion, and drug resistance, making SOX9 a potential biomarker for tumor prognosis and progression. This review systematically summarizes the latest findings of SOX9 in hepatobiliary development, homeostasis, and disease. We also highlight the value of SOX9 as a novel biomarker and potential target for the clinical treatment of major liver diseases.

Keywords

Biliary systemCancerHomeostasisLiver diseasesSOX9

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Genes & Diseases
Volume 11 Issue 4,
July 2024
Article number: 100996
DOI: 10.1016/j.gendis.2023.03.035

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Cite this article:
Shang T, Jiang T, Cui X, et al. Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases. Genes & Diseases, 2024, 11(4): 100996. https://doi.org/10.1016/j.gendis.2023.03.035

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Received: 26 July 2022
Revised: 13 February 2023
Accepted: 19 March 2023
Published: 24 June 2023
© 2023 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).