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Rapid Communication | Open Access

A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis

Xinghui Lia,b,1( ), Haiping Wanga,b,1, Yandi Wua,b,1, Li Zouc, Shijie Denga,b, Xinlu Fua,b, Tongsheng Huanga,b, Conghui Shena,b, Teng Wua,b, Weibin Caia,b,d( )
Guangdong Engineering & Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China
Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518107, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work and are joint first authors.

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Genes & Diseases
Volume 11 Issue 1,
January 2024
Pages 11-14
DOI: 10.1016/j.gendis.2023.01.011

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Li X, Wang H, Wu Y, et al. A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis. Genes & Diseases, 2024, 11(1): 11-14. https://doi.org/10.1016/j.gendis.2023.01.011

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Received: 28 October 2022
Published: 23 March 2023
© 2023 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).