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Rapid Communication | Open Access

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

Zhenhai Lia, Wenchao Xub, Feng Chena, Jun Zhanga( ), Wei-Guo Zhua,c,d,e ( )
Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, Guangdong 518055, China
School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, Guangdong 518055, China
Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen University Health Science Center, Shenzhen, Guangdong 518055, China
Shenzhen Bay Laboratory, Shenzhen University School of Medicine, Shenzhen, Guangdong 518055, China
Marshall Laboratory of Biomedical Engineering, Shenzhen University School of Medicine, Shenzhen, Guangdong 518055, China

Peer review under responsibility of Chongqing Medical University.

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Genes & Diseases
Pages 19-22

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Cite this article:
Li Z, Xu W, Chen F, et al. BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response. Genes & Diseases, 2024, 11(1): 19-22. https://doi.org/10.1016/j.gendis.2022.12.001

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Received: 28 September 2022
Published: 31 December 2022
© 2022 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).