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Rapid Communication | Open Access

Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2

Fatimah A. Alsaffara,1, Ahmed H. Mujamammia,2, Mohammed S.K. Aldughaima,3, Martin J.H. Nicklinb, Michael D. Barkera( )
Department of Oncology & Metabolism, University of Sheffield Medical School, Sheffield S10 2RX, UK
Department of Infection Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield S10 2RX, UK

1Current address: Department of Clinical Laboratory Sciences, Alghad International Colleges for Applied Medical Sciences, Dammam, Kingdom of Saudi Arabia.

2Current address: Department of Pathology and Laboratory Medicine, College of Medicine and King Saud University Medical City Hospitals, King Saud University, P.O. Box 2925, Riyadh 11461, Kingdom of Saudi Arabia.

3Current address: Research Center, King Fahad Medical City, P.O.Box. 59046, Riyadh 11525, Kingdom of Saudi Arabia.

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Genes & Diseases
Volume 10 Issue 1,
January 2023
Pages 45-47
DOI: 10.1016/j.gendis.2022.03.008

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Cite this article:
Alsaffar FA, Mujamammi AH, Aldughaim MS, et al. Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2. Genes & Diseases, 2023, 10(1): 45-47. https://doi.org/10.1016/j.gendis.2022.03.008

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Published: 12 April 2022
© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).