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Rapid Communication | Open Access

Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease

Eva Gijbelsa,b,1, Kevin De Muynckb,c,1, Bart Vanderborghtc,b, Tim Meesed,e, Filip Van Nieuwerburghd,e, Aude Vanlanderf, Frederik Berrevoetf, Bart Hendrikxf, Anne Hoorensg, Hans Van Vlierbergheh, Mathieu Vinkena,1, Lindsey Devisscherb,1( )
Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, 1090 Brussels, Belgium
Gut-Liver Immunopharmacology Unit, Basic and Applied Medical Sciences; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium
Hepatology Research Unit, Internal Medicine and Paediatrics; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium
Lab of Pharmaceutical Biotechnology, Ghent University, 9000 Ghent, Belgium
NXTGNT, Ghent University, 9000 Ghent, Belgium
Department of HPB Surgery and Liver Transplantation, Ghent University Hospital, 9000 Ghent, Belgium
Department of Pathology, Ghent University Hospital, 9000 Ghent, Belgium
Hepatology Research Unit, Internal Medicine and Paediatrics; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium

1These authors contributed equally to this work.

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Genes & Diseases
Volume 10 Issue 1,
January 2023
Pages 18-21
DOI: 10.1016/j.gendis.2022.02.003

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Cite this article:
Gijbels E, De Muynck K, Vanderborght B, et al. Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease. Genes & Diseases, 2023, 10(1): 18-21. https://doi.org/10.1016/j.gendis.2022.02.003

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Published: 14 March 2022
© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).