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Rapid Communication | Open Access

A complex signature network that controls the upregulation of PRMT5 in colorectal cancer

Han Weia,d,1Antja-Voy Hartleya,e,1Aishat Motolania,1Guanglong JiangbAhmad SafaaLakshmi Prabhua,fYunlong LiubTao Lua,b,c( )
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
Department of Medical & Molecular Genetics, Indiana University School of Medicine, 975 W. Walnut Street, Indianapolis, IN 46202, USA
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
Current address: Beckman Coulter Life Sciences, 5350 Lakeview Pkwy S Dr, Indianapolis, IN 46268, USA
Current address: Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave., Boston, MA 02215, USA
Current address: Gilead Sciences, Inc., 333 Lakeside Drive Foster City, CA 94404, USA

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed to this work equally.

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References

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Xiao W, Chen X, Liu L, Shu Y, Zhang M, Zhong Y. Role of protein arginine methyltransferase 5 in human cancers. Biomed Pharmacother. 2019;114: e108790.

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Prabhu L, Wei H, Chen L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8(25): 39963-39977.

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Paek AR, Mun JY, Jo MJ, et al. The role of ZNF143 in breast cancer cell survival through the NAD(P)H quinone dehydrogenase 1-p53-beclin1 axis under metabolic stress. Cells. 2019;8(4): e296.

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Zhang HT, Zeng LF, He QY, Tao WA, Zha ZG, Hu CD. The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5. Biochim Biophys Acta. 2016;1863(2): 335-346.

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Dibrov A, Kashour T, Amara FM. The role of transforming growth factor beta signaling in messenger RNA stability. Growth Factors. 2006;24(1): 1-11.

Genes & Diseases
Pages 285-287
Cite this article:
Wei H, Hartley A-V, Motolani A, et al. A complex signature network that controls the upregulation of PRMT5 in colorectal cancer. Genes & Diseases, 2022, 9(2): 285-287. https://doi.org/10.1016/j.gendis.2021.11.001

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Received: 17 September 2021
Published: 26 November 2021
© 2021, Chongqing Medical University. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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