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Review Article | Open Access

SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine

Xia Huanga,b, Qiuman Chena,b, Wenping Luoa,b,c, Mikhail Pakvasac,d,e, Yuxin Zhanga,b, Liwen Zhenga,b, Shuang Lia,b, Zhuohui Yanga,b, Huan Zenga,b, Fang Lianga,b, Fugui Zhanga,b,c, Daniel A. Huc, Kevin H. Qinc, Eric J. Wangc, David S. Qinc, Russell R. Reidc,e, Tong-Chuan Hec,e, Aravind Athivirahamc, Mostafa El Dafrawyc, Hongmei Zhanga,c,f( )
Stomatological Hospital of Chongqing Medical University, Chongqing 401147, PR China
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, PR China
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA
The Pritzker School of Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA
Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA
Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, PR China

Peer review under responsibility of Chongqing Medical University.

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Abstract

SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator, SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific, and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells, SATB2 plays a significant role in craniofacial pattern and skeleton development. In addition to regulating osteogenic differentiation, SATB2 also displays versatile functions in neural development and cancer progression. As an osteoinductive factor, SATB2 holds great promise in improving bone regeneration toward bone defect repair. In this review, we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development, neurogenesis, tumorigenesis and regenerative medicine.

Keywords

Bone regenerationDevelopmentNeurogenesisSATB2Tumorigenesis

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Genes & Diseases
Volume 9 Issue 1,
January 2022
Pages 95-107
DOI: 10.1016/j.gendis.2020.10.003

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Cite this article:
Huang X, Chen Q, Luo W, et al. SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine. Genes & Diseases, 2022, 9(1): 95-107. https://doi.org/10.1016/j.gendis.2020.10.003

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Received: 30 June 2020
Revised: 30 August 2020
Accepted: 06 October 2020
Published: 17 October 2020
© 2020, Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).