Notch signaling: Its essential roles in bone and craniofacial development

Mikhail Pakvasa; Pranav Haravu; Michael Boachie-Mensah; Alonzo Jones; Elam Coalson; Junyi Liao; Zongyue Zeng; Di Wu; Kevin Qin; Xiaoxing Wu; Huaxiu Luo; Jing Zhang; Meng Zhang; Fang He; Yukun Mao; Yongtao Zhang; Changchun Niu; Meng Wu; Xia Zhao; Hao Wang; Linjuan Huang; Deyao Shi; Qing Liu; Na Ni; Kai Fu; Michael J. Lee; Jennifer Moriatis Wolf; Aravind Athiviraham; Sherwin S. Ho; Tong-Chuan He; Kelly Hynes; Jason Strelzow; Mostafa El Dafrawy; Russell R. Reid

doi:10.1016/j.gendis.2020.04.006

Genes & Diseases 2021, 8(1): 8-24 https://doi.org/10.1016/j.gendis.2020.04.006

Review Article |

Open Access | Issue | Published: 11 April 2020

Notch signaling: Its essential roles in bone and craniofacial development

Show Author's Information Hide Author's Information Mikhail Pakvasa^{^a^,^b^,^c^,}, Pranav Haravu^{^b}, Michael Boachie-Mensah^{^a^,^b}, Alonzo Jones^{^b}, Elam Coalson^{^a^,^b}, Junyi Liao^{^a^,^d}, Zongyue Zeng^{^a^,^e}, Di Wu^{^a}, Kevin Qin^{^a}, Xiaoxing Wu^{^a^,^d}, Huaxiu Luo^{^a^,^f}, Jing Zhang^{^a^,^d}, Meng Zhang^{^a^,^g}, Fang He^{^a^,^d}, Yukun Mao^{^a^,^h}, Yongtao Zhang^{^a^,ⁱ}, Changchun Niu^{^a^,^j}, Meng Wu^{^a^,^k}, Xia Zhao^{^a^,ⁱ}, Hao Wang^{^a^,^e}, Linjuan Huang^{^a^,^d}, Deyao Shi^{^a^,^l}, Qing Liu^{^a^,^m}, Na Ni^{^a^,^e}, Kai Fu^{^a^,^h}, Michael J. Lee^{^a}, Jennifer Moriatis Wolf^{^a}, Aravind Athiviraham^{^a}, Sherwin S. Ho^{^a}, Tong-Chuan He^{^a}, Kelly Hynes^{^a}, Jason Strelzow^{^a}, Mostafa El Dafrawy^{^a}, Russell R. Reid^{^a^,^c}(

)

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA

Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA

Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA

Departments of Orthopaedic Surgery, Gastrointestinal Surgery, Obstetrics and Gynecology, and Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China

Ministry of Education Key Laboratory of Diagnostic Medicine, and School of Laboratory and Diagnostic Medicine, Chongqing Medical University, Chongqing, 400016, PR China

Department of Burn and Plastic Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, PR China

Department of Orthopaedic Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, PR China

Departments of Orthopaedic Surgery and Neurosurgery, The Affiliated Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430072, PR China

Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266061, PR China

Department of Laboratory Diagnostic Medicine, Chongqing General Hospital, Chongqing, 400021, PR China

Institute of Bone and Joint Research, and the Department of Orthopaedic Surgery, The Second Hospitals of Lanzhou University, Gansu, Lanzhou, 730030, PR China

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430072, PR China

Department of Spine Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China

Peer review under responsibility of Chongqing Medical University.

Keywords:

Osteogenesis, Bone, Alagille syndrome, Notch, Craniosynostosis, Oncogenesis, Craniofacial development, Spondylocostal dysosotosis

Cite this article:

Pakvasa M, Haravu P, Boachie-Mensah M, et al. Notch signaling: Its essential roles in bone and craniofacial development. Genes & Diseases, 2021, 8(1): 8-24. https://doi.org/10.1016/j.gendis.2020.04.006

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Abstract About this article

Abstract

Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future.

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Publication history

Received: 25 February 2020

Revised: 25 March 2020

Accepted: 03 April 2020

Published: 11 April 2020

Issue date: January 2021

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Acknowledgements

The reported work was supported in part by research grants from the National Institutes of Health (CA226303to TCH), the U.S. Department of Defense (OR130096 to JMW) and the Scoliosis Research Society (TCH and MJL). MP was supported in part by the Pritzker-Northshore Fellowship at The University of Chicago. WW was supported by the Medical Scientist Training Program of the National Institutes of Health (T32 GM007281). This project was also supported in part by The University of Chicago Cancer Center Support Grant (P30CA014599) and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1 TR000430. TCH was supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund. Funding sources were not involved in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).