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Genes & Diseases 2020, 7(4): 598-605 https://doi.org/10.1016/j.gendis.2020.03.005
Review Article | Open Access | Issue | Published: 19 March 2020

The functions of N6-methyladenosine modification in lncRNAs

Show Author's Information Rong-Zhang Hea,b,1( ),  Jing Jiangb,c,1,  Di-Xian Luob,c( )
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China
Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People’s Hospital of Chenzhou, University of South China, Chenzhou, 423000, China
Center for Clinical Pathology, The First People’s Hospital of Chenzhou, University of South China, Chenzhou, 423000, People’s Republic of China

Peer review under responsibility of Chongqing Medical University.

1 These authors have contributed equally to this work.

Keywords:
LncRNA, N6-methyladenosine, Erasers, Readers, Writers
Cite this article:
He R-Z, Jiang J, Luo D-X. The functions of N6-methyladenosine modification in lncRNAs. Genes & Diseases, 2020, 7(4): 598-605. https://doi.org/10.1016/j.gendis.2020.03.005
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Abstract About this article

Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA. Extensive studies of m6A modification of mRNAs have been carried out, while little is known about m6A modification of long non-coding RNAs (lncRNAs). Recently, several studies reported m6A modification of lncRNAs. In this review, we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.

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Publication history

Received: 11 December 2019
Revised: 05 March 2020
Accepted: 08 March 2020
Published: 19 March 2020
Issue date: December 2020

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© 2020, Chongqing Medical University.

Acknowledgements

This work was supported by the Natural Science Foundation of China (81773165), Hunan Province Science Fund for Distinguished Young Scholars (2018JJ1021), the Key R&D Program of Hunan Province (2017SK2172), and the Science and Technology Foundation of Chenzhou (jsyf2017023).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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