Journal Home > Volume 6 , Issue 1
Genes & Diseases 2019, 6(1): 6-15 https://doi.org/10.1016/j.gendis.2019.01.003
Review Article | Open Access | Issue | Published: 11 February 2019

Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Show Author's Information Rong-Zhang Hea,b,c,  Di-Xian Luob,  Yin-Yuan Moc,( )
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078 Hunan, China
Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People’s Hospital of Chenzhou of University of South China, Chenzhou, 432000, China
Department of Pharmacology/Toxicology, and Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA

Peer review under responsibility of Chongqing Medical University.

Keywords:
Alternative splicing, LncRNA, Posttranscriptional regulation, Protein stability, RNA binding proteins, RNA stability
Cite this article:
He R-Z, Luo D-X, Mo Y-Y. Emerging roles of lncRNAs in the post-transcriptional regulation in cancer. Genes & Diseases, 2019, 6(1): 6-15. https://doi.org/10.1016/j.gendis.2019.01.003
Download citation
EndNote(RIS)
BibTeX

134

Views

1

Downloads

Citations

156

Crossref

N/A

WoS

157

Scopus

0

CSCD

Abstract About this article

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.

Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Received: 20 December 2018
Accepted: 21 January 2019
Published: 11 February 2019
Issue date: March 2019

Copyright

© 2019, Chongqing Medical University.

Acknowledgements

Acknowledgement

This work was supported by NIH grant R01 CA154989 (YM).

Rights and permissions

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Return