Journal Home > Volume 5 , Issue 1
Genes & Diseases 2018, 5(1): 9-15 https://doi.org/10.1016/j.gendis.2017.11.005
Review Article | Open Access | Issue | Published: 24 November 2017

Role of genetic and environmental factors in DNA methylation of lipid metabolism

Show Author's Information Zhen Hea,  Rong Zhanga,  Feng Jianga,  Wenjing Houc,( ),  Cheng Hua,b,( )
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
Institute for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, China
Fengxian Central Hospital, Affiliated to Southern Medical University, 6600 Nanfeng Road, Shanghai, 201499, China

Peer review under responsibility of Chongqing Medical University.

Keywords:
DNA methylation, Gene expression, Lipid metabolism, Environmental exposure, Genetic variations
Cite this article:
He Z, Zhang R, Jiang F, et al. Role of genetic and environmental factors in DNA methylation of lipid metabolism. Genes & Diseases, 2018, 5(1): 9-15. https://doi.org/10.1016/j.gendis.2017.11.005
Download citation
EndNote(RIS)
BibTeX

153

Views

1

Downloads

Citations

20

Crossref

N/A

WoS

20

Scopus

0

CSCD

Abstract About this article

A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors into phenotypic traits. Therefore, elucidating the factors that underlie inter-individual DNA methylation variations gives us an opportunity to predict diseases and interfere with the establishment of aberrant DNA methylation early. In this review, we summarize the findings of DNA methylation-related studies focused on unravelling the potential role of genetic and environmental factors in DNA methylation and the regulatory effect of DNA methylation on gene expression in lipid metabolism.

Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Received: 05 September 2017
Accepted: 17 November 2017
Published: 24 November 2017
Issue date: March 2018

Copyright

© 2017, Chongqing Medical University.

Acknowledgements

This work was supported by the grant from Outstanding Academic Leaders of Shanghai Heath System [2017BR008].

Rights and permissions

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Return