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Genes & Diseases 2017, 4(4): 185-195 https://doi.org/10.1016/j.gendis.2017.10.002
Review Article | Open Access | Issue | Published: 02 November 2017

3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends

Show Author's Information Elliot S. Bishopa,b,,  Sami Mostafac,  Mikhail Pakvasac,  Hue H. Luub,  Michael J. Leeb,  Jennifer Moriatis Wolfb,  Guillermo A. Ameerd,e,  Tong-Chuan Heb,  Russell R. Reida( )
Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medicine, Chicago, IL 60637, USA
Molecular Oncology Laboratory, Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA
The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60616, USA

Peer review under responsibility of Chongqing Medical University.

Keywords:
3D printing, Additive manufacturing, Tissue engineering, CAD/CAM, Bioprinting
Cite this article:
Bishop ES, Mostafa S, Pakvasa M, et al. 3-D bioprinting technologies in tissue engineering and regenerative medicine: Current and future trends. Genes & Diseases, 2017, 4(4): 185-195. https://doi.org/10.1016/j.gendis.2017.10.002
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Abstract About this article

Advances in three-dimensional (3D) printing have increased feasibility towards the synthesis of living tissues. Known as 3D bioprinting, this technology involves the precise layering of cells, biologic scaffolds, and growth factors with the goal of creating bioidentical tissue for a variety of uses. Early successes have demonstrated distinct advantages over conventional tissue engineering strategies. Not surprisingly, there are current challenges to address before 3D bioprinting becomes clinically relevant. Here we provide an overview of 3D bioprinting technology and discuss key advances, clinical applications, and current limitations. While 3D bioprinting is a relatively novel tissue engineering strategy, it holds great potential to play a key role in personalized medicine.

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Publication history

Received: 21 October 2017
Accepted: 26 October 2017
Published: 02 November 2017
Issue date: December 2017

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© 2017, Chongqing Medical University.

Acknowledgements

Acknowledgements

Research in the authors’ laboratories was supported in part by research grants from the National Institutes of Health (AT004418, DE020140 to TCH and RRR), the US Department of Defense (OR130096 to JMW), the Chicago Biomedical Consortium with support from the Searle Funds at The Chicago Community Trust (RRR, GAA and TCH), the Scoliosis Research Society (TCH and MJL), a Cleft Palate Foundation Research Support Grant (RRR), and the National Key Research and Development Program of China (2016YFC1000803 and 2011CB707906 to TCH). SM and MP were recipients of the Pritzker Summer Research Fellowship funded through the National Institute of Health (NIH) T-35 training grant (NIDDK). Funding sources were not involved in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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