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Perspective | Open Access

An NgAgo tool for genome editing: did CRISPR/Cas9 just find a competitor?

Qiang Wei, Junyi Liao, Xinyi Yu, Eric J. Wang, Claire Wang, Hue H. Luu, Rex C. Haydon, Michael J. Lee, Tong-Chuan He( )
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA

Peer review under responsibility of Chongqing Medical University.

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Abstract

While CRISPR/Cas9-mediated genome editing technology has been experiencing a rapid transformation during the past few years, a recent report on NgAgo-mediated single-stranded DNA-guided genome editing may offer an attractive alternative for genome manipulation. While it’s too early to predict whether NgAgo will be able to compete with or be superior to CRISPR/Cas9, the scientific community is anxiously waiting for further optimization and broader applications of the NgAgo genome editing technology.

Keywords

ArgonautesCas9CRISPRGenome editinggRNA guideNgAgoNucleasesssDNA guide

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Genes & Diseases
Volume 3 Issue 3,
September 2016
Pages 169-170
DOI: 10.1016/j.gendis.2016.06.001

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Cite this article:
Wei Q, Liao J, Yu X, et al. An NgAgo tool for genome editing: did CRISPR/Cas9 just find a competitor?. Genes & Diseases, 2016, 3(3): 169-170. https://doi.org/10.1016/j.gendis.2016.06.001

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Received: 16 June 2016
Published: 09 July 2016
© 2016 Chongqing Medical University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).