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Food Science and Human Wellness 2023, 12(6): 2286-2296 https://doi.org/10.1016/j.fshw.2023.03.048
Research Article | Open Access | Issue | Published: 04 April 2023

Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice

Show Author's Information Jing Lia,1,  Xinyue Yua,b,1,  Xinxing Xua,  Peipei Tangc,  Shuang Bia,  Xiaopu Rend,  Yong Shie,  Jihong Wua( ),  Fei Laoa( )
National Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Beijing Daily Chemical Products Quality Supervision and Inspection Station, Beijing 101111, China
Department of Food Science and Technology, The Ohio State University, Columbus 43210, USA
College of Food Science and Engineering, Tarim University, Alar 843300, China
Haoxiangni Health Food Co., Ltd., Xinzheng 451100, China

1 The authors contributed equally to this work.

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Gut microbiota, Probiotics, Short-chain fatty acid, Lactic acid bacteria fermentation, Jujube
Cite this article:
Li J, Yu X, Xu X, et al. Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice. Food Science and Human Wellness, 2023, 12(6): 2286-2296. https://doi.org/10.1016/j.fshw.2023.03.048
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Abstract Full text About this article

Unfermented jujube pulp (UFJP), fermented jujube pulp (FJP) in high and low doses were fed to constipated ICR mice. Defecation function, serum gastrointestinal regulatory peptide, fecal short-chain fatty acids (SCFAs) and gut microbial composition were assessed. Results showed that high-dose FJP could protect intestinal mucosa tissue, shorten the first black feces defecating time by 17% and increase the number and wet weights of black feces by 72% and 71%, respectively, within 6 h. High-dose FJP significantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice, compared with low-dose FJP and UFJP. High-dose FJP intervention regulated the microbiota profile, which afterwards restored microbiota, like Bacteroidetes, Bifidobacterium and Lactobacillus, to a less unhealthy state. This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.


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About this article

Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice

Show Author's information Jing Lia,1, Xinyue Yua,b,1, Xinxing Xua, Peipei Tangc, Shuang Bia, Xiaopu Rend, Yong Shie, Jihong Wua( ), Fei Laoa( )
National Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing Key Laboratory for Food Non-thermal Processing, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Beijing Daily Chemical Products Quality Supervision and Inspection Station, Beijing 101111, China
Department of Food Science and Technology, The Ohio State University, Columbus 43210, USA
College of Food Science and Engineering, Tarim University, Alar 843300, China
Haoxiangni Health Food Co., Ltd., Xinzheng 451100, China

1 The authors contributed equally to this work.

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Unfermented jujube pulp (UFJP), fermented jujube pulp (FJP) in high and low doses were fed to constipated ICR mice. Defecation function, serum gastrointestinal regulatory peptide, fecal short-chain fatty acids (SCFAs) and gut microbial composition were assessed. Results showed that high-dose FJP could protect intestinal mucosa tissue, shorten the first black feces defecating time by 17% and increase the number and wet weights of black feces by 72% and 71%, respectively, within 6 h. High-dose FJP significantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice, compared with low-dose FJP and UFJP. High-dose FJP intervention regulated the microbiota profile, which afterwards restored microbiota, like Bacteroidetes, Bifidobacterium and Lactobacillus, to a less unhealthy state. This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.

Keywords: Gut microbiota, Probiotics, Short-chain fatty acid, Lactic acid bacteria fermentation, Jujube

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Received: 08 September 2021
Revised: 26 April 2022
Accepted: 12 June 2022
Published: 04 April 2023
Issue date: November 2023

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© 2023 Beijing Academy of Food Sciences.

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This research was supported by the Chinese Universities Scientific Fund (2022TC124) and open foundation of Beijing Advanced Innovation Center for Food Nutrition and Human Health.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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