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Food Science and Human Wellness 2023, 12(6): 2135-2150 https://doi.org/10.1016/j.fshw.2023.03.027
Review Article | Open Access | Issue | Published: 04 April 2023

Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review

Show Author's Information Xiaochun Yanga,  Deyong Zenga,  Chongyang Lib,  Wenchen Yua,  Guilin Xieb,  Yingchun Zhanga( ),  Weihong Lua,b,c( )
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
Sichuan Gongda Southwest Food Research Co., Ltd., Bazhong 636063, China
The Intelligent Equipment Research Center for the Exploitation of Characteristic Food & Medicine Resources, Chongqing Research Institute of Harbin Institute of Technology, Chongqing 401135, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Pathogenesis, Signaling pathway, Action mechanism, Colitis, Oligosaccharides
Cite this article:
Yang X, Zeng D, Li C, et al. Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review. Food Science and Human Wellness, 2023, 12(6): 2135-2150. https://doi.org/10.1016/j.fshw.2023.03.027
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Abstract Full text About this article

Inflammatory bowel disease (IBD) is characterized by recurrent attacks and long courses, and the number of patients has expanded rapidly year by year. Additionally, current conventional strategies exist serious adverse effects. In this case, it is an urgent issue to find out an effective and safe treatment. Functional oligosaccharides possess safe and excellent physiological activities, and have attracted enormous attention due to their great therapeutic potential for IBD. This review emphasizes the attenuating effects of distinct functional oligosaccharides on IBD and their structure, and summarizes the main mechanisms from the aspects of regulating intestinal flora structure, repairing intestinal barrier, modulating immune function and mediating related signaling pathways in order to reveal the relationship between functional oligosaccharides, immune regulation, intestinal epithelial cells, gut flora and IBD treatment. Oligosaccharides possess excellent protective effects on IBD, and can be considered as safe and functional ingredients in the health food and pharmaceutical industry.


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About this article

Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review

Show Author's information Xiaochun Yanga, Deyong Zenga, Chongyang Lib, Wenchen Yua, Guilin Xieb, Yingchun Zhanga( ), Weihong Lua,b,c( )
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
Sichuan Gongda Southwest Food Research Co., Ltd., Bazhong 636063, China
The Intelligent Equipment Research Center for the Exploitation of Characteristic Food & Medicine Resources, Chongqing Research Institute of Harbin Institute of Technology, Chongqing 401135, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Inflammatory bowel disease (IBD) is characterized by recurrent attacks and long courses, and the number of patients has expanded rapidly year by year. Additionally, current conventional strategies exist serious adverse effects. In this case, it is an urgent issue to find out an effective and safe treatment. Functional oligosaccharides possess safe and excellent physiological activities, and have attracted enormous attention due to their great therapeutic potential for IBD. This review emphasizes the attenuating effects of distinct functional oligosaccharides on IBD and their structure, and summarizes the main mechanisms from the aspects of regulating intestinal flora structure, repairing intestinal barrier, modulating immune function and mediating related signaling pathways in order to reveal the relationship between functional oligosaccharides, immune regulation, intestinal epithelial cells, gut flora and IBD treatment. Oligosaccharides possess excellent protective effects on IBD, and can be considered as safe and functional ingredients in the health food and pharmaceutical industry.

Keywords: Pathogenesis, Signaling pathway, Action mechanism, Colitis, Oligosaccharides

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Publication history

Received: 02 November 2021
Revised: 29 November 2021
Accepted: 29 December 2021
Published: 04 April 2023
Issue date: November 2023

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© 2023 Beijing Academy of Food Sciences.

Acknowledgements

This work was financially supported by Sichuan Science and Technology Program [2021YFSY0035] and Heilongjiang Touyan Team [HITTY-20190034].

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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