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Food Science and Human Wellness 2023, 12(6): 2029-2039 https://doi.org/10.1016/j.fshw.2023.03.018
Research Article | Open Access | Issue | Published: 04 April 2023

Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats

Show Author's Information Xin Xiaoa,  Ochuko L. Erukainurea,b,  Md. Shahidul Islama( )
Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa
Department of Pharmacology, University of the Free State, Bloemfontein 9300, South Africa

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Antioxidants, Type 2 diabetes, Red honeybush tea (Cyclopia genistoides), Anti-diabetes
Cite this article:
Xiao X, Erukainure OL, Islam MS. Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats. Food Science and Human Wellness, 2023, 12(6): 2029-2039. https://doi.org/10.1016/j.fshw.2023.03.018
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Abstract Full text About this article

Red honeybush tea (RHT) is a tea product developed from Cyclopia spp. which is endemic to South Africa. Aside refreshment, RHT has over the years been used traditionally in the treatment of various diseases including type 2 diabetes. This study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes (T2D) model of rats. T2D was induced starting with feeding 10% fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight (BW)). Five weeks of treatment of RHT led to significant (P < 0.05) elevation in serum insulin, pancreatic β-cell function, HDL-c levels with concomitant decrease in AST, ALT, ALP, urea, CK-MB, fructosamine, total cholesterol, triglycerides, LDL-c, and insulin resistance in diabetic rats. RHT also significantly (P < 0.05) decreased MDA levels and enhanced level of GSH, activity of SOD, catalase, GR in most of organs (pancreas, liver, kidneys, and heart). Significantly (P < 0.05) improved morphological changes in the islets and β-cells were observed in rats treated with RHT. The data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.


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About this article

Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats

Show Author's information Xin Xiaoa, Ochuko L. Erukainurea,b, Md. Shahidul Islama( )
Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa
Department of Pharmacology, University of the Free State, Bloemfontein 9300, South Africa

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Red honeybush tea (RHT) is a tea product developed from Cyclopia spp. which is endemic to South Africa. Aside refreshment, RHT has over the years been used traditionally in the treatment of various diseases including type 2 diabetes. This study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes (T2D) model of rats. T2D was induced starting with feeding 10% fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight (BW)). Five weeks of treatment of RHT led to significant (P < 0.05) elevation in serum insulin, pancreatic β-cell function, HDL-c levels with concomitant decrease in AST, ALT, ALP, urea, CK-MB, fructosamine, total cholesterol, triglycerides, LDL-c, and insulin resistance in diabetic rats. RHT also significantly (P < 0.05) decreased MDA levels and enhanced level of GSH, activity of SOD, catalase, GR in most of organs (pancreas, liver, kidneys, and heart). Significantly (P < 0.05) improved morphological changes in the islets and β-cells were observed in rats treated with RHT. The data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.

Keywords: Antioxidants, Type 2 diabetes, Red honeybush tea (Cyclopia genistoides), Anti-diabetes

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Publication history

Received: 10 March 2021
Revised: 22 March 2021
Accepted: 09 May 2021
Published: 04 April 2023
Issue date: November 2023

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© 2023 Beijing Academy of Food Sciences.

Acknowledgements

Acknowledgements

This study was supported by a competitive research grant from the Research Office, University of KwaZulu-Natal (UKZN), Durban; an incentive grant for rated researchers and a grant support for women and young researchers from the National Research Foundation (NRF), Pretoria, South Africa.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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