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Food Science and Human Wellness 2023, 12(4): 1157-1166 https://doi.org/10.1016/j.fshw.2022.10.041
Research Article | Open Access | Issue | Published: 18 November 2022

Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats

Show Author's Information Ligang Yanga,  Chao Yanga,  Zhixiu Songb,  Min Wana,  Hui Xiaa,  Xian Yanga,  Dengfeng Xua,  Da Pana,  Hechun Liua,  Shaokang Wanga,  Guiju Suna( )
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
Second Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Polyunsaturated fatty acid, n-6 Fatty acids, n-3 Fatty acids;, Postprandial metabolism, Hypertriglyceridemia
Cite this article:
Yang L, Yang C, Song Z, et al. Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats. Food Science and Human Wellness, 2023, 12(4): 1157-1166. https://doi.org/10.1016/j.fshw.2022.10.041
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Abstract Full text About this article

Postprandial metabolism plays major roles in many pathological conditions. The n-6/n-3 polyunsaturated fatty acid (PUFA) ratio is closely related to various physiological disorders. This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control (NC) and hypertriglyceridemia (HTG) rats. The postprandial response of triglyceride (TG) in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals. The HTG groups showed higher postprandial total cholesterol (TC) responses than NC groups after 1:1 and 20:1 ratio meals. The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factor α (TNF-α) than 1:1 and 10:1 ratios in HTG groups. The postprandial malondialdehyde (MDA) response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups. The 1:1 ratio resulted in a lower postprandial reactive oxygen species (ROS) level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups. The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats. A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.


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About this article

Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats

Show Author's information Ligang Yanga, Chao Yanga, Zhixiu Songb, Min Wana, Hui Xiaa, Xian Yanga, Dengfeng Xua, Da Pana, Hechun Liua, Shaokang Wanga, Guiju Suna( )
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
Second Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Postprandial metabolism plays major roles in many pathological conditions. The n-6/n-3 polyunsaturated fatty acid (PUFA) ratio is closely related to various physiological disorders. This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control (NC) and hypertriglyceridemia (HTG) rats. The postprandial response of triglyceride (TG) in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals. The HTG groups showed higher postprandial total cholesterol (TC) responses than NC groups after 1:1 and 20:1 ratio meals. The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factor α (TNF-α) than 1:1 and 10:1 ratios in HTG groups. The postprandial malondialdehyde (MDA) response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups. The 1:1 ratio resulted in a lower postprandial reactive oxygen species (ROS) level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups. The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats. A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.

Keywords: Polyunsaturated fatty acid, n-6 Fatty acids, n-3 Fatty acids;, Postprandial metabolism, Hypertriglyceridemia

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Received: 15 May 2021
Revised: 24 June 2021
Accepted: 15 September 2021
Published: 18 November 2022
Issue date: July 2023

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© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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This work was supported by National Key Research and Development Plan (2016YFD0400604) and National Natural Science Foundation of China (82073551).

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