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Food Science and Human Wellness 2023, 12(4): 1053-1063 https://doi.org/10.1016/j.fshw.2022.10.023
Research Article | Open Access | Issue | Published: 18 November 2022

Probiotics supplementation for management of type Ⅱ diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial

Show Author's Information Chengcheng Zhanga,b,1,  Yingyue Shengc,1,  Jinchi Jianga,b,  Yuzheng Xuec,  Leilei Yua,b,  Fengwei Tiana,b,  Jianxin Zhaoa,b,  Hao Zhanga,b,d,e,  Jian Jinf( ),  Qixiao Zhaia,b( )
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi 214122, China
National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi 214122, China
School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China

1 These authors distributed equally in this study.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Keywords:
Meta-analysis, Type 2 diabetes, Probiotic, Polycystic ovary syndrome, Glucose homeostasis, Randomized clinical trial
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Zhang C, Sheng Y, Jiang J, et al. Probiotics supplementation for management of type Ⅱ diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial. Food Science and Human Wellness, 2023, 12(4): 1053-1063. https://doi.org/10.1016/j.fshw.2022.10.023
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Abstract Full text About this article

This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome (PCOS). The meta-analysis was performed in accordance with the Cochrane Handbook guidelines and relevant the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria. Of 825 identified reports, 11 randomized clinical trials were included in the meta-analysis. An analysis of pooled extracted data revealed that supplementation with probiotics significantly decreased fasting blood glucose (FBG, n = 7; standardized mean difference (SMD) = −0.40; 95% confidence interval (CI): −2.02, −0.02; P = 0.04) and insulin levels (n = 6; SMD = −0.57; 95% CI: −0.89, −0.25; P = 0.0004) and the homeostatic model assessment of insulin resistance (n = 7; SMD = −0.64; 95% CI: −0.96, −0.31; P = 0.0001) while increasing the quantitative insulin sensitivity check index (QUICKI, n = 5; SMD = 0.58; 95% CI: 0.08, 1.09; P = 0.02) in patients with PCOS. The FBG-reducing effect decreased as the baseline body mass index (BMI) and mean age of the participants increased. Indeed, a greater number of bacterial species and a higher bacterial dose were shown to reduce QUICKI effectively. The systematic review indicated that probiotic supplementation may help to control glucose homeostasis in adults with polycystic ovarian syndrome.


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About this article

Probiotics supplementation for management of type Ⅱ diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial

Show Author's information Chengcheng Zhanga,b,1, Yingyue Shengc,1, Jinchi Jianga,b, Yuzheng Xuec, Leilei Yua,b, Fengwei Tiana,b, Jianxin Zhaoa,b, Hao Zhanga,b,d,e, Jian Jinf( ), Qixiao Zhaia,b( )
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi 214122, China
National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi 214122, China
School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China

1 These authors distributed equally in this study.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Abstract

This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome (PCOS). The meta-analysis was performed in accordance with the Cochrane Handbook guidelines and relevant the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria. Of 825 identified reports, 11 randomized clinical trials were included in the meta-analysis. An analysis of pooled extracted data revealed that supplementation with probiotics significantly decreased fasting blood glucose (FBG, n = 7; standardized mean difference (SMD) = −0.40; 95% confidence interval (CI): −2.02, −0.02; P = 0.04) and insulin levels (n = 6; SMD = −0.57; 95% CI: −0.89, −0.25; P = 0.0004) and the homeostatic model assessment of insulin resistance (n = 7; SMD = −0.64; 95% CI: −0.96, −0.31; P = 0.0001) while increasing the quantitative insulin sensitivity check index (QUICKI, n = 5; SMD = 0.58; 95% CI: 0.08, 1.09; P = 0.02) in patients with PCOS. The FBG-reducing effect decreased as the baseline body mass index (BMI) and mean age of the participants increased. Indeed, a greater number of bacterial species and a higher bacterial dose were shown to reduce QUICKI effectively. The systematic review indicated that probiotic supplementation may help to control glucose homeostasis in adults with polycystic ovarian syndrome.

Keywords: Meta-analysis, Type 2 diabetes, Probiotic, Polycystic ovary syndrome, Glucose homeostasis, Randomized clinical trial

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Publication history

Received: 20 July 2021
Revised: 09 August 2021
Accepted: 08 September 2021
Published: 18 November 2022
Issue date: July 2023

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© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

This work was supported by the National Natural Science Foundation of China Program (31871773 and 32001665); the Natural Science Foundation of Jiangsu Province (BK20200084); National First-Class Discipline Program of Food Science and Technology (JUFSTR20180102); Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province; the Wuxi Health and Family Planning Commission (ZDRC039); High-level Health Talents in Jiangsu Province (LGY2018016).

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