The beneficial effects of Tartary buckwheat (<i>Fagopyrum tataricum</i> Gaertn.) on diet-induced obesity in mice are related to the modulation of gut microbiota composition

Yiming Zhou; Haoyu Lu; Shen Zhao; Beibei Yan; Hong Wang; Xiaoli Zhou; Ying Xiao

doi:10.1016/j.fshw.2022.10.014

Food Science and Human Wellness 2023, 12(4): 1323-1330 https://doi.org/10.1016/j.fshw.2022.10.014

Research Article |

Open Access | Issue | Published: 18 November 2022

The beneficial effects of Tartary buckwheat (Fagopyrum tataricum Gaertn.) on diet-induced obesity in mice are related to the modulation of gut microbiota composition

Show Author's Information Hide Author's Information Yiming Zhou^{^a}, Haoyu Lu^{^a}, Shen Zhao^{^a}, Beibei Yan^{^b}, Hong Wang^{^a}, Xiaoli Zhou^{^a^,^b}(

), Ying Xiao^{^a}

School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China

University Think Tank of Shanghai Municipality, Institute of Beautiful China and Ecological Civilization, Shanghai 201418, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:

Gut microbiota, High-fat diet, Lipid metabolism, Tartary buckwheat, Biochemical parameters

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Zhou Y, Lu H, Zhao S, et al. The beneficial effects of Tartary buckwheat (Fagopyrum tataricum Gaertn.) on diet-induced obesity in mice are related to the modulation of gut microbiota composition. Food Science and Human Wellness, 2023, 12(4): 1323-1330. https://doi.org/10.1016/j.fshw.2022.10.014

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Abstract

The gut is home to a large number of intestinal microbiota that play an important role in the metabolism and immune system of the host. A growing body of evidence suggests that a high-fat diet is closely associated with many metabolic disorders, including fatty liver and type 2 diabetes. According to reports, Tartary buckwheat extract has a positive effect on intestinal microbiota in animals. The effects of Tartary buckwheat on biochemical indexes and intestinal microflora in mice were studied. Tartary buckwheat protein (FGP), Tartary buckwheat resistant starch (FGS) and Tartary buckwheat flour (FGF) alleviated organ damage in mice and lowered the atherosclerotic index (AI) in plasma. Otherwise, principal coordinate analysis (PCoA) showed that intestinal bacterial structure of FGF were separated apparently from other groups. The Firmicutes/Bacteroidetes (F/B) value of the high-fat (HF)-FGF group was significantly lower than that of the HF-FGP and HF-FGS groups. FGF significantly increases the abundance of beneficial bacteria such as Bifidobacterium, while decreasing the abundance of lipopolysaccharide (LPS)-producing bacteria. Observation of blood lipid metabolism parameters and analysis of the intestinal microbiota suggested that FGF can be more effective than FGP and FGS to reduce the effects of a high-fat diet in mice, restoring the blood parameters to values similar of those in mice fed a low-fat diet. FGF may be used to prevent or treat blood lipid metabolism disorders and intestinal microbiota disorders in mice fed a high-fat diet.

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The beneficial effects of Tartary buckwheat (Fagopyrum tataricum Gaertn.) on diet-induced obesity in mice are related to the modulation of gut microbiota composition

Show Author's information Hide Author's Information Yiming Zhou^{^a}, Haoyu Lu^{^a}, Shen Zhao^{^a}, Beibei Yan^{^b}, Hong Wang^{^a}, Xiaoli Zhou^{^a^,^b}(

), Ying Xiao^{^a}

School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China

University Think Tank of Shanghai Municipality, Institute of Beautiful China and Ecological Civilization, Shanghai 201418, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Keywords: Gut microbiota, High-fat diet, Lipid metabolism, Tartary buckwheat, Biochemical parameters

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Publication history

Received: 13 June 2021

Revised: 12 July 2021

Accepted: 16 August 2021

Published: 18 November 2022

Issue date: July 2023

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Acknowledgements

The authors thank Shanghai Natural Science Foundation (20ZR1455800), the National Science Foundation of China (31871805), Shanghai Municipal Education Commission (Plateau Discipline Construction Program) and China Agriculture Research System (CARS-08-D2). And we thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).