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Food Science and Human Wellness 2023, 12(4): 1212-1223 https://doi.org/10.1016/j.fshw.2022.10.003
Research Article | Open Access | Issue | Published: 18 November 2022

The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis

Show Author's Information Changhui Dua,  Zhenjie Lia,  Jing Zhanga,  Ni Yina,  Lirong Tanga,  Jie Lia,  Jingyin Suna,  Xiaoqing Yua,  Wei Chenb,  Hang Xiaoc,  Xian Wud( ),  Xuexiang Chena( )
School of Public Health, Guangzhou Medical University, Guangzhou 510642, China
Department of Information Systems and Analytics, Miami University, Oxford 45056, USA
Department of Food Science, University of Massachusetts, Amherst 01003, USA
Department of Kinesiology, Nutrition, and Health, Miami University, Oxford 45056, USA

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Gut microbiota, Inflammatory bowel diseases, Metabolites, Colitis, Carnosic acid
Cite this article:
Du C, Li Z, Zhang J, et al. The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis. Food Science and Human Wellness, 2023, 12(4): 1212-1223. https://doi.org/10.1016/j.fshw.2022.10.003
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Abstract Full text About this article

Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Carnosic acid (CA) is a major antioxidant component of rosemary and sage. Herein, we investigated the protective effects of dietary CA on dextran sodium sulfate (DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota. We found that CA effectively attenuated DSS-stimulated colitis in mice, as evidenced by reduced disease activity index (DAI), and systemic and colonic inflammation. Additionally, CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice. Moreover, Spearman's correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species. Changes in gut microbiota and the correlated metabolites might partially explain CA's anti-inflammatory effects against colitis. Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.


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About this article

The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis

Show Author's information Changhui Dua, Zhenjie Lia, Jing Zhanga, Ni Yina, Lirong Tanga, Jie Lia, Jingyin Suna, Xiaoqing Yua, Wei Chenb, Hang Xiaoc, Xian Wud( ), Xuexiang Chena( )
School of Public Health, Guangzhou Medical University, Guangzhou 510642, China
Department of Information Systems and Analytics, Miami University, Oxford 45056, USA
Department of Food Science, University of Massachusetts, Amherst 01003, USA
Department of Kinesiology, Nutrition, and Health, Miami University, Oxford 45056, USA

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Carnosic acid (CA) is a major antioxidant component of rosemary and sage. Herein, we investigated the protective effects of dietary CA on dextran sodium sulfate (DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota. We found that CA effectively attenuated DSS-stimulated colitis in mice, as evidenced by reduced disease activity index (DAI), and systemic and colonic inflammation. Additionally, CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice. Moreover, Spearman's correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species. Changes in gut microbiota and the correlated metabolites might partially explain CA's anti-inflammatory effects against colitis. Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.

Keywords: Gut microbiota, Inflammatory bowel diseases, Metabolites, Colitis, Carnosic acid

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Publication history

Received: 13 February 2022
Revised: 03 April 2022
Accepted: 21 April 2022
Published: 18 November 2022
Issue date: July 2023

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© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgment

This study was supported by Natural Science Foundation of Guangdong basic and applied basic research foundation (2021A1515010965), General project of Basic and applied basic Research in Guangzhou (202102080241), Laboratory opening project of Guangzhou Medical University (PX-1020423), Natural Science Foundation of Guangdong basic and applied basic research foundation ([2018]105), Guangdong Provincial Department of Education (S202010570042) and Communist Youth League Committee of Guangzhou Medical University (2019A060).

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