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Food Science and Human Wellness 2023, 12(3): 920-928 https://doi.org/10.1016/j.fshw.2022.09.029
Research Article | Open Access | Issue | Published: 15 October 2022

Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy

Show Author's Information Jingxin Gaoa,  Tiange Lib,  Dong Liangc,  Han Gonga,  Liang Zhaoa,  Xueying Maoa( )
Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Henan Engineering Technology Research Center of Food Processing and Circulation Safety Control, College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
Applied Nutrition I, China National Center for Food Safety Risk Assessment, Beijing 100022, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Immune response, Intestinal barrier, Offspring, Cow’s milk allergy, Maternal obesity
Cite this article:
Gao J, Li T, Liang D, et al. Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy. Food Science and Human Wellness, 2023, 12(3): 920-928. https://doi.org/10.1016/j.fshw.2022.09.029
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Abstract Full text About this article

Food allergy has become a significant public health problem affecting a large number of people worldwide. Maternal obesity causes inflammation and alters the immune system of offspring, which may exacerbate their food allergy. The aim of this study was to determine whether offspring mice born to obese mothers would have more serve reactions to cow’s milk protein-induced food allergy, and further investigate the underlying mechanisms. Female offspring BALB/c mice of mothers with normal and high-fat diets were sensitized with β-lactoglobulin (BLG), respectively. Maternal obesity increased the serum immunoglobulin E and mouse mast cell protease levels, though did not have significant influence on anaphylactic symptom score, core temperature and diarrhea rate of offspring mice after BLG sensitization. Furthermore, maternal obesity led to a lower level of occludin mRNA expression in BLG -sensitized mice. The mice born to obese mothers exhibited increased mRNA expression levels of GATA-3, interleukin (IL)-4 and IL-10 in jejunum after BLG sensitization, indicating maternal obesity intensified Th2-type biased immune responses. In conclusion, maternal obesity exerted exacerbating effects on the responsiveness of their offspring to cow’s milk protein sensitization.


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About this article

Maternal obesity exacerbates the responsiveness of offspring BALB/c mice to cow’s milk protein-induced food allergy

Show Author's information Jingxin Gaoa, Tiange Lib, Dong Liangc, Han Gonga, Liang Zhaoa, Xueying Maoa( )
Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Henan Engineering Technology Research Center of Food Processing and Circulation Safety Control, College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
Applied Nutrition I, China National Center for Food Safety Risk Assessment, Beijing 100022, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Food allergy has become a significant public health problem affecting a large number of people worldwide. Maternal obesity causes inflammation and alters the immune system of offspring, which may exacerbate their food allergy. The aim of this study was to determine whether offspring mice born to obese mothers would have more serve reactions to cow’s milk protein-induced food allergy, and further investigate the underlying mechanisms. Female offspring BALB/c mice of mothers with normal and high-fat diets were sensitized with β-lactoglobulin (BLG), respectively. Maternal obesity increased the serum immunoglobulin E and mouse mast cell protease levels, though did not have significant influence on anaphylactic symptom score, core temperature and diarrhea rate of offspring mice after BLG sensitization. Furthermore, maternal obesity led to a lower level of occludin mRNA expression in BLG -sensitized mice. The mice born to obese mothers exhibited increased mRNA expression levels of GATA-3, interleukin (IL)-4 and IL-10 in jejunum after BLG sensitization, indicating maternal obesity intensified Th2-type biased immune responses. In conclusion, maternal obesity exerted exacerbating effects on the responsiveness of their offspring to cow’s milk protein sensitization.

Keywords: Immune response, Intestinal barrier, Offspring, Cow’s milk allergy, Maternal obesity

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Publication history

Received: 08 February 2022
Revised: 20 February 2022
Accepted: 04 March 2022
Published: 15 October 2022
Issue date: May 2023

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© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgements

This work was supported by the National Key Research and Development Program of China (2019YFC1605000) and the Beijing Dairy Industry Innovation Team (BAIC06-2021).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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