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Food Science and Human Wellness 2023, 12(3): 711-719 https://doi.org/10.1016/j.fshw.2022.09.004
Review Article | Open Access | Issue | Published: 15 October 2022

Association of nutrients intake during pregnancy with the risk of allergic disease in offspring: a meta-analysis of prospective cohort studies

Show Author's Information Hua Fenga,b,  Yan Chenc,  Xiujuan Xiongd,  Qunying Xub,  Zhongwei Zhangb,  Qinghua Xib,  Yongning Wua,c( ),  Yuanan Lue( )
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330006, China
School of Public Health, Nanchang University, Nanchang 330006, China
Research Unit of Food Safety (2019RU014), Chinese Academy of Medical Sciences; NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment (CFSA), Beijing 100022, China
Department of Pathology, School of Basic Medical Sciences, Nanchang University, Nanchang 330006, China
Environmental Health Laboratory, Department of Public Health Sciences, University of Hawaii, Honolulu 96822, US

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Pregnancy, Allergy, Nutrients, Offspring, Immune disease
Cite this article:
Feng H, Chen Y, Xiong X, et al. Association of nutrients intake during pregnancy with the risk of allergic disease in offspring: a meta-analysis of prospective cohort studies. Food Science and Human Wellness, 2023, 12(3): 711-719. https://doi.org/10.1016/j.fshw.2022.09.004
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Abstract Full text About this article

To investigate the role of nutrients intake during pregnancy with longitudinal development of rhinitis, asthma, eczema, wheeze, and food allergy in offspring. The PubMed, Embase, and Cochrane library were searched for articles published throughout May 2022. The pooled effect estimate were presented using relative risk and calculated by the random-effects model. Twenty-three prospective cohort studies enrolling 210817 individuals were included. The risk of wheeze in offspring were lowered when high vitamin D, vitamin E, zinc, and milk intakes during pregnancy, whereas high meat intake during pregnancy could induce additional risk of wheeze in offspring. Moreover, high β-carotene and magnesium intakes during pregnancy were related to lower eczema risk in offspring, whereas eczema risk in offspring was increased for pregnant women with high intake of butter and margarine. Finally, the asthma risk in offspring could protect against for pregnant women with high intake of vitamin D and apple, whereas high folic acid during pregnancy could produce excess asthma risk in offspring. This study provides the summary evidences regarding the role of nutrients intake during pregnancy and subsequent risk of rhinitis, asthma, eczema, wheeze, and food allergy, and further effective intervention strategies should be employed to improve childhood allergic diseases.


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About this article

Association of nutrients intake during pregnancy with the risk of allergic disease in offspring: a meta-analysis of prospective cohort studies

Show Author's information Hua Fenga,b, Yan Chenc, Xiujuan Xiongd, Qunying Xub, Zhongwei Zhangb, Qinghua Xib, Yongning Wua,c( ), Yuanan Lue( )
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330006, China
School of Public Health, Nanchang University, Nanchang 330006, China
Research Unit of Food Safety (2019RU014), Chinese Academy of Medical Sciences; NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment (CFSA), Beijing 100022, China
Department of Pathology, School of Basic Medical Sciences, Nanchang University, Nanchang 330006, China
Environmental Health Laboratory, Department of Public Health Sciences, University of Hawaii, Honolulu 96822, US

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

To investigate the role of nutrients intake during pregnancy with longitudinal development of rhinitis, asthma, eczema, wheeze, and food allergy in offspring. The PubMed, Embase, and Cochrane library were searched for articles published throughout May 2022. The pooled effect estimate were presented using relative risk and calculated by the random-effects model. Twenty-three prospective cohort studies enrolling 210817 individuals were included. The risk of wheeze in offspring were lowered when high vitamin D, vitamin E, zinc, and milk intakes during pregnancy, whereas high meat intake during pregnancy could induce additional risk of wheeze in offspring. Moreover, high β-carotene and magnesium intakes during pregnancy were related to lower eczema risk in offspring, whereas eczema risk in offspring was increased for pregnant women with high intake of butter and margarine. Finally, the asthma risk in offspring could protect against for pregnant women with high intake of vitamin D and apple, whereas high folic acid during pregnancy could produce excess asthma risk in offspring. This study provides the summary evidences regarding the role of nutrients intake during pregnancy and subsequent risk of rhinitis, asthma, eczema, wheeze, and food allergy, and further effective intervention strategies should be employed to improve childhood allergic diseases.

Keywords: Pregnancy, Allergy, Nutrients, Offspring, Immune disease

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Received: 27 April 2022
Revised: 12 May 2022
Accepted: 02 July 2022
Published: 15 October 2022
Issue date: May 2023

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© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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This study was supported by CAMS Innovation Fund for Medical Science (CIFMS 2019-I2M-5-024).

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