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Food Science and Human Wellness 2023, 12(2): 454-466 https://doi.org/10.1016/j.fshw.2022.07.047
Research Article | Open Access | Issue | Published: 07 September 2022

Creating burdock polysaccharide-oleanolic acid-ursolic acid nanoparticles to deliver enhanced anti-inflammatory effects: fabrication, structural characterization and property evaluation

Show Author's Information Shanshan Zhua,1,  Zhichang Qiua,1,  Xuguang Qiaoa,  Geoffrey I.N. Waterhouseb,  Wenqing Zhua,  Wenting Zhaoc,  Qiuxia Hed( ),  Zhenjia Zhenga( )
Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes, College of Food Science and Engineering, Shandong Agricultural University, Tai’an 271018, China
The School of Chemical Sciences, The University of Auckland, Auckland 1025, New Zealand
Institute of Agri-food Processing and Nutrition, Vegetable Research Center, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China

1 These authors contributed equally to this work.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Keywords:
Particle size, Encapsulation, Thermodynamic properties, Structural features, Zeta potential, In vivo verification
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Zhu S, Qiu Z, Qiao X, et al. Creating burdock polysaccharide-oleanolic acid-ursolic acid nanoparticles to deliver enhanced anti-inflammatory effects: fabrication, structural characterization and property evaluation. Food Science and Human Wellness, 2023, 12(2): 454-466. https://doi.org/10.1016/j.fshw.2022.07.047
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Abstract Full text About this article

This study explored the potential of polysaccharides from Actium lappa (ALPs) as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid (OA) and ursolic acid (UA). Encapsulating OA+UA with ALPs (ALP:OA+UA, 50:1; OA:UA, 1:1) changed the crystalline nature to a more amorphous state through hydrogen bonding and involving O-H/C-O/O-C-O groups. ALP-OA/UA nanoparticles had a particle size and zeta potential (in water) of 199.1 nm/-7.15 mV, with a narrow unimodal size distribution, and excellent pH, salt solution, temperature and storage stability. Compared with ALPs, ALP-OA/UA nanoparticles showed enhanced anti-inflammatory activity (especially at a dose of 100 μg/mL) in a CuSO4-induced zebrafish inflammation model via down-regulating the NF-κB signalling pathway and gene expression of associated transcription factors and cytokines (TNF-α, IL-1β and IL-8). Therefore, ALP-based nanoparticles are natural and anti-inflammatory carriers for hydrophobic bioactive molecules.


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About this article

Creating burdock polysaccharide-oleanolic acid-ursolic acid nanoparticles to deliver enhanced anti-inflammatory effects: fabrication, structural characterization and property evaluation

Show Author's information Shanshan Zhua,1, Zhichang Qiua,1, Xuguang Qiaoa, Geoffrey I.N. Waterhouseb, Wenqing Zhua, Wenting Zhaoc, Qiuxia Hed( ), Zhenjia Zhenga( )
Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes, College of Food Science and Engineering, Shandong Agricultural University, Tai’an 271018, China
The School of Chemical Sciences, The University of Auckland, Auckland 1025, New Zealand
Institute of Agri-food Processing and Nutrition, Vegetable Research Center, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China

1 These authors contributed equally to this work.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Abstract

This study explored the potential of polysaccharides from Actium lappa (ALPs) as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid (OA) and ursolic acid (UA). Encapsulating OA+UA with ALPs (ALP:OA+UA, 50:1; OA:UA, 1:1) changed the crystalline nature to a more amorphous state through hydrogen bonding and involving O-H/C-O/O-C-O groups. ALP-OA/UA nanoparticles had a particle size and zeta potential (in water) of 199.1 nm/-7.15 mV, with a narrow unimodal size distribution, and excellent pH, salt solution, temperature and storage stability. Compared with ALPs, ALP-OA/UA nanoparticles showed enhanced anti-inflammatory activity (especially at a dose of 100 μg/mL) in a CuSO4-induced zebrafish inflammation model via down-regulating the NF-κB signalling pathway and gene expression of associated transcription factors and cytokines (TNF-α, IL-1β and IL-8). Therefore, ALP-based nanoparticles are natural and anti-inflammatory carriers for hydrophobic bioactive molecules.

Keywords: Particle size, Encapsulation, Thermodynamic properties, Structural features, Zeta potential, In vivo verification

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Publication history

Received: 23 December 2021
Revised: 24 January 2022
Accepted: 22 February 2022
Published: 07 September 2022
Issue date: March 2023

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© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgements

This work was supported by the Shandong Provincial Natural Science Foundation of China (ZR2019BC100), Science, Education and Industry Integration Innovation Pilot Project of Qilu University of Technology (Shandong Academy of Sciences) (2020KJC-ZD10) and Incubation Program of Youth Innovation in Shandong Province.

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