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Food Science and Human Wellness 2023, 12(2): 442-453 https://doi.org/10.1016/j.fshw.2022.07.046
Research Article | Open Access | Issue | Published: 07 September 2022

Polysaccharide extract from Rosa laevigata fruit attenuates inflammatory obesity by targeting redox balance and gut interface in high-fat diet-fed rats

Show Author's Information Xuejiao Zhanga,b,  Chenzhong Jinc,  Han Liuc,  Yihong Huc,  Yunyun Zhouc,  Weiguo Wua( ),  Si Qina( )
Lab of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China
College of Food and Chemical Engineering, Shaoyang University, Shaoyang, 422000, China
Collaborative Innovation Center for Field Weeds Control, Hunan University of Humanities, Science and Technology, Loudi 417000, China
Keywords:
Gut microbiota, Redox, Multi-omics, Polysaccharides, Rosa laevigata
Cite this article:
Zhang X, Jin C, Liu H, et al. Polysaccharide extract from Rosa laevigata fruit attenuates inflammatory obesity by targeting redox balance and gut interface in high-fat diet-fed rats. Food Science and Human Wellness, 2023, 12(2): 442-453. https://doi.org/10.1016/j.fshw.2022.07.046
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Abstract Full text About this article

Low-molecular-weight polysaccharides (RLPs) extracted from Rosa laevigata fruits showed multiple biofunctions in Asia. This study aimed to investigate its anti-inflammatory obesity effect in high-fat diet-fed rats and further elucidated the underlying molecular mechanism by multi-omics methods. The results showed that RLPs administration had significantly restored immune organ indexes and reduced body weight gain. RNA-seq revealed that the effect of RLPs was partially attributed to its regulation on PPARs signaling by increasing the expressions of Scd, Acox3 and Hmgcs2, and on other redox-related pathways by decreasing the expressions of Cyp2e1, Il1-r1 and Lbp. Moreover, 16S rRNA sequencing coupled with metagenome sequencing showed that RLPs had significantly reduced the ratio of Firmicutes/Bacteroidetes from 8.01 to 2.37, and significantly increased the relative abundances of Alistipes, Prevotella, and Akkermansia from 0.36%, 1.10% and 2.61% to 0.65%, 2.37% and 4.42%, respectively. Spearman correlation analysis result indicated that the abundances of Lachnospiraceae, Prevotella and Bacteroidales were significantly negatively correlated with obesity phenotype, liver function and inflammatory factors. These results revealed that RLPs exerted significant anti-inflammatory obesity property partially via regulation on gut microbiota interface and the redox balance. Therefore, RLPs could be a promising functional food resource with the potential for redox imbalance-related diseases chemoprevention.


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About this article

Polysaccharide extract from Rosa laevigata fruit attenuates inflammatory obesity by targeting redox balance and gut interface in high-fat diet-fed rats

Show Author's information Xuejiao Zhanga,b, Chenzhong Jinc, Han Liuc, Yihong Huc, Yunyun Zhouc, Weiguo Wua( ), Si Qina( )
Lab of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China
College of Food and Chemical Engineering, Shaoyang University, Shaoyang, 422000, China
Collaborative Innovation Center for Field Weeds Control, Hunan University of Humanities, Science and Technology, Loudi 417000, China

Abstract

Low-molecular-weight polysaccharides (RLPs) extracted from Rosa laevigata fruits showed multiple biofunctions in Asia. This study aimed to investigate its anti-inflammatory obesity effect in high-fat diet-fed rats and further elucidated the underlying molecular mechanism by multi-omics methods. The results showed that RLPs administration had significantly restored immune organ indexes and reduced body weight gain. RNA-seq revealed that the effect of RLPs was partially attributed to its regulation on PPARs signaling by increasing the expressions of Scd, Acox3 and Hmgcs2, and on other redox-related pathways by decreasing the expressions of Cyp2e1, Il1-r1 and Lbp. Moreover, 16S rRNA sequencing coupled with metagenome sequencing showed that RLPs had significantly reduced the ratio of Firmicutes/Bacteroidetes from 8.01 to 2.37, and significantly increased the relative abundances of Alistipes, Prevotella, and Akkermansia from 0.36%, 1.10% and 2.61% to 0.65%, 2.37% and 4.42%, respectively. Spearman correlation analysis result indicated that the abundances of Lachnospiraceae, Prevotella and Bacteroidales were significantly negatively correlated with obesity phenotype, liver function and inflammatory factors. These results revealed that RLPs exerted significant anti-inflammatory obesity property partially via regulation on gut microbiota interface and the redox balance. Therefore, RLPs could be a promising functional food resource with the potential for redox imbalance-related diseases chemoprevention.

Keywords: Gut microbiota, Redox, Multi-omics, Polysaccharides, Rosa laevigata

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Received: 16 July 2021
Revised: 16 July 2021
Accepted: 22 November 2021
Published: 07 September 2022
Issue date: March 2023

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