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Food Science and Human Wellness 2023, 12(2): 378-396 https://doi.org/10.1016/j.fshw.2022.07.040
Review Article | Open Access | Issue | Published: 07 September 2022

Mushroom β-glucan and polyphenol formulations as natural immunity boosters and balancers: nature of the application

Show Author's Information Maja Kozarskia( ),  Anita Klausa,  Leo van Griensvenb,  Dragica Jakovljevicc,  Nina Todorovicc,  Wan Abd Al Qadr Imad Wan-Mohtard,  Jovana Vunduke
Institute of Food Technology and Biochemistry, Faculty of Agriculture, University of Belgrade, Belgrade 11080, Serbia
Plant Research International, Wageningen University and Research Centre, Wageningen 6700 AA, the Netherlands
Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade 11000, Serbia
Functional Omics and Bioprocess Development Laboratory, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Institute of General and Physical Chemistry, University of Belgrade, Belgrade 11158, Serbia
Keywords:
Mushrooms, Polyphenols, β-Glucan, Immunity boosters, Superfood, Natural cosmetics
Cite this article:
Kozarski M, Klaus A, van Griensven L, et al. Mushroom β-glucan and polyphenol formulations as natural immunity boosters and balancers: nature of the application. Food Science and Human Wellness, 2023, 12(2): 378-396. https://doi.org/10.1016/j.fshw.2022.07.040
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Abstract Full text About this article

Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet. These valuable organisms are more than food, they fit in perfectly as a novel market group known as nutra-mycoceuticals. Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry. Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients. This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers, β-glucans. The literature data on their bioavailability, metabolic transformations, preclinical and human clinical research, and safety are discussed. Immunomodulatory mechanisms of polyphenol ingredients are also considered. These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity. Finally, we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.


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About this article

Mushroom β-glucan and polyphenol formulations as natural immunity boosters and balancers: nature of the application

Show Author's information Maja Kozarskia( ), Anita Klausa, Leo van Griensvenb, Dragica Jakovljevicc, Nina Todorovicc, Wan Abd Al Qadr Imad Wan-Mohtard, Jovana Vunduke
Institute of Food Technology and Biochemistry, Faculty of Agriculture, University of Belgrade, Belgrade 11080, Serbia
Plant Research International, Wageningen University and Research Centre, Wageningen 6700 AA, the Netherlands
Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade 11000, Serbia
Functional Omics and Bioprocess Development Laboratory, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Institute of General and Physical Chemistry, University of Belgrade, Belgrade 11158, Serbia

Abstract

Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet. These valuable organisms are more than food, they fit in perfectly as a novel market group known as nutra-mycoceuticals. Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry. Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients. This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers, β-glucans. The literature data on their bioavailability, metabolic transformations, preclinical and human clinical research, and safety are discussed. Immunomodulatory mechanisms of polyphenol ingredients are also considered. These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity. Finally, we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.

Keywords: Mushrooms, Polyphenols, β-Glucan, Immunity boosters, Superfood, Natural cosmetics

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Received: 16 February 2022
Revised: 22 March 2022
Accepted: 14 April 2022
Published: 07 September 2022
Issue date: March 2023

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© 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgment

This review was the result of research within the “Agreement on the implementation and financing of scientific research work in 2022 between the Faculty of Agriculture in Belgrade and the Ministry of Education, Science and Technological Development of the Republic of Serbia”, contract record number: 451-03-68/2022-14/200116, 451-03-68/2022-14/200051 and supported by the Science Fund of the Republic of Serbia, #Grant No: 7748088, “Composite clays as advanced materials in animal nutrition and biomedicineAniNutBiomedCLAYs”.

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