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Food Science and Human Wellness 2022, 11(6): 1475-1481 https://doi.org/10.1016/j.fshw.2022.06.004
Research Article | Open Access | Issue | Published: 18 July 2022

The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods

Show Author's Information Zhiwei Zhoua,1,  Dan Wangb,1,  Wei Liua,  Lang Heb,  Pengkuan Lianga,  Junli Haob,  Qun Suna( )
Key Laboratory of Bio-resources and Eco-environment Ministry of the Education, College of Life Sciences, Sichuan University, Chengdu 610064, China
School of Biomedical Sciences and Technology, Chengdu Medical College, Chengdu 610500, China

1 These authors contributed to the work equally and should be regarded as co-first authors.

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Cytokines, Functional foods, Porcine placenta, Immunity promoting activity, Phagocytic rate
Cite this article:
Zhou Z, Wang D, Liu W, et al. The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods. Food Science and Human Wellness, 2022, 11(6): 1475-1481. https://doi.org/10.1016/j.fshw.2022.06.004
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Abstract Full text About this article

This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods. Porcine placenta was subjected to the analysis for its bioactive substances, and their immunity-promoting activity was determined in mice supplemented with porcine placenta extract (PPE) and freeze-dried porcine placenta powder at high (PPH) and low (PPL) dosage. Results showed that porcine placenta contained placental peptides and 15 free amino acids, and the amounts of estrogen and progesterone in products developed from porcine placenta were within the limit of national standard. Mice model experiment revealed that compared with the control, the PPH treatment significantly improved the spleen index (P < 0.05) by increasing the phagocytic rate of macrophages from 20% to 60% and the conversion rate of T lymphocytes from 8% to 60%. The qPCR analysis disclosed that the porcine placenta powder enhanced mice immunity via promoting the expression of Th1 cytokines of interleukin-2 (IL-2) and IFN-γ, especially the former, by almost 8 times in the spleens of male mice, while inhibited Th2 cytokines of IL-4 and IL-10. This investigation has provided a reference for the development of porcine placenta as a raw material applied in functional foods to improve human immunity.


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Abstract
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About this article

The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods

Show Author's information Zhiwei Zhoua,1, Dan Wangb,1, Wei Liua, Lang Heb, Pengkuan Lianga, Junli Haob, Qun Suna( )
Key Laboratory of Bio-resources and Eco-environment Ministry of the Education, College of Life Sciences, Sichuan University, Chengdu 610064, China
School of Biomedical Sciences and Technology, Chengdu Medical College, Chengdu 610500, China

1 These authors contributed to the work equally and should be regarded as co-first authors.

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods. Porcine placenta was subjected to the analysis for its bioactive substances, and their immunity-promoting activity was determined in mice supplemented with porcine placenta extract (PPE) and freeze-dried porcine placenta powder at high (PPH) and low (PPL) dosage. Results showed that porcine placenta contained placental peptides and 15 free amino acids, and the amounts of estrogen and progesterone in products developed from porcine placenta were within the limit of national standard. Mice model experiment revealed that compared with the control, the PPH treatment significantly improved the spleen index (P < 0.05) by increasing the phagocytic rate of macrophages from 20% to 60% and the conversion rate of T lymphocytes from 8% to 60%. The qPCR analysis disclosed that the porcine placenta powder enhanced mice immunity via promoting the expression of Th1 cytokines of interleukin-2 (IL-2) and IFN-γ, especially the former, by almost 8 times in the spleens of male mice, while inhibited Th2 cytokines of IL-4 and IL-10. This investigation has provided a reference for the development of porcine placenta as a raw material applied in functional foods to improve human immunity.

Keywords: Cytokines, Functional foods, Porcine placenta, Immunity promoting activity, Phagocytic rate

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Publication history
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Publication history

Received: 11 April 2020
Revised: 02 July 2020
Accepted: 06 July 2020
Published: 18 July 2022
Issue date: November 2022

Copyright

© 2022 Beijing Academy of Food Sciences.

Acknowledgements

Acknowledgements

This work was supported by grants from the National Key Research and Development Projects (2019YFE0103800), Scientific Research Project of Sichuan Provincial Health Department (No. 18PJ586) and Research and Innovation Team Project of Chengdu Medical College (No. CYTD16-04).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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