Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice

Mengxue Song; Dehong Tan; Bin Li; Yanqun Wang; Lin Shi

doi:10.1016/j.fshw.2022.04.029

Food Science and Human Wellness 2022, 11(5): 1347-1354 https://doi.org/10.1016/j.fshw.2022.04.029

Research Article |

Open Access | Issue | Published: 02 June 2022

Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice

Show Author's Information Hide Author's Information Mengxue Song^{^a}, Dehong Tan^{^a^,^b}, Bin Li^{^a^,^b}, Yanqun Wang^{^a^,^b}, Lin Shi^{^a^,^b}(

)

College of Food Science, Shenyang Agricultural University, Shenyang 110866, China

Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province, Shenyang Agricultural University, Shenyang 110866, China

Keywords:

Diabetes, Insulin resistance, Gynostemma pentaphyllum, Gluconeogenesis, Gypenosides, Adenosine monophosphate-activated protein kinase (AMPK)

Cite this article:

Song M, Tan D, Li B, et al. Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice. Food Science and Human Wellness, 2022, 11(5): 1347-1354. https://doi.org/10.1016/j.fshw.2022.04.029

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Abstract

Gynostemma pentaphyllum, also called "Southern Ginseng" in China, is a traditional Asian folk medicinal plant. Gypenosides (Gps) are the biologically active constituents of G. pentaphyllum, which have been reported with hypoglycemic activity. However, the underlying mechanisms are unclear. The effects of two Gps (Gp-Ⅰ and Gp-Ⅱ) on type 2 diabetic mellitus (T2DM) mice, induced by high-fat and high-sugar diet and streptozotocin, were evaluated to explore the mechanism of their hypoglycemic actions. Gps reduced fasting blood glucose and serum lipids, as well as significantly improved T2DM mice glucose tolerance and insulin resistance (IR). After Gps treatment, the severity of liver injury was reduced and liver glycogen content increased. In addition, Gps promoted the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), and downregulated the key proteins phosphoenolpyruvate carboxy kinase and glucose-6 phosphatase, in the AMPK signaling pathway. Thus, our study suggests that Gps mediate hepatic gluconeogenesis and improve IR via activating AMPK signaling pathway in T2DM mice.

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Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice

Show Author's information Hide Author's Information Mengxue Song^{^a}, Dehong Tan^{^a^,^b}, Bin Li^{^a^,^b}, Yanqun Wang^{^a^,^b}, Lin Shi^{^a^,^b}(

)

College of Food Science, Shenyang Agricultural University, Shenyang 110866, China

Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province, Shenyang Agricultural University, Shenyang 110866, China

Abstract

Keywords: Diabetes, Insulin resistance, Gynostemma pentaphyllum, Gluconeogenesis, Gypenosides, Adenosine monophosphate-activated protein kinase (AMPK)

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Publication history

Received: 17 November 2020

Revised: 14 January 2021

Accepted: 08 March 2021

Published: 02 June 2022

Issue date: September 2022

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81602983).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).