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Food Science and Human Wellness 2022, 11(5): 1177-1182 https://doi.org/10.1016/j.fshw.2022.04.013
Research Article | Open Access | Issue | Published: 02 June 2022

Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action

Show Author's Information Wenping Tanga,b,1,  Jianfeng Zhana,1,  Shiming Lia( ),  Yue Liuc,  Chi-Tang Hob( )
Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, China
Department of Food Science, Rutgers University, New Brunswick 08901, USA
Department of Chemical Biology, Rutgers University, Piscataway 08901, USA

1 Authors contributed equally.

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Diabetes, Hypoglycemic activity, Stilbene glycoside, Polygonum multiflorum, Homeostatic model assessment
Cite this article:
Tang W, Zhan J, Li S, et al. Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action. Food Science and Human Wellness, 2022, 11(5): 1177-1182. https://doi.org/10.1016/j.fshw.2022.04.013
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Abstract Full text About this article

In 2021, there are approximately 537 million adults ageing 2079 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating diseases such as diabetes. Both as a food and an herbal medicine, Polygonum multiflorum (PM) has been used as an anti-aging tonic, for hair darkening in traditional Chinese medicine for several centuries. The recent research effort of PM has been focused on antioxidant, anti-ageing and anti-tumor properties. In the present study, we utilized the traditional processing of harvested raw PM, and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract (PME). PME (0.075%) was given to diabetic mice (KK CgAy/J) in drinking water and after 7 weeks, PME-treated mice had significantly lower glucose levels than mice in the diabetic control group (P < 0.01). The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintaining β-cell function.


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About this article

Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action

Show Author's information Wenping Tanga,b,1, Jianfeng Zhana,1, Shiming Lia( ), Yue Liuc, Chi-Tang Hob( )
Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, China
Department of Food Science, Rutgers University, New Brunswick 08901, USA
Department of Chemical Biology, Rutgers University, Piscataway 08901, USA

1 Authors contributed equally.

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

In 2021, there are approximately 537 million adults ageing 2079 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating diseases such as diabetes. Both as a food and an herbal medicine, Polygonum multiflorum (PM) has been used as an anti-aging tonic, for hair darkening in traditional Chinese medicine for several centuries. The recent research effort of PM has been focused on antioxidant, anti-ageing and anti-tumor properties. In the present study, we utilized the traditional processing of harvested raw PM, and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract (PME). PME (0.075%) was given to diabetic mice (KK CgAy/J) in drinking water and after 7 weeks, PME-treated mice had significantly lower glucose levels than mice in the diabetic control group (P < 0.01). The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintaining β-cell function.

Keywords: Diabetes, Hypoglycemic activity, Stilbene glycoside, Polygonum multiflorum, Homeostatic model assessment

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Publication history
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Publication history

Received: 09 September 2020
Revised: 23 November 2020
Accepted: 20 December 2020
Published: 02 June 2022
Issue date: September 2022

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© 2022 Beijing Academy of Food Sciences.

Acknowledgements

Acknowledgement

This work was supported by Hubei Science and Technology Plan key Project, Hubei Province, China (2019ABA100).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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