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Food Science and Human Wellness 2022, 11(4): 914-921 https://doi.org/10.1016/j.fshw.2022.03.017
Research Article | Open Access | Issue | Published: 28 April 2022

Evaluation of silymarin extract from Silybum marianum in mice: anti-fatigue activity

Show Author's Information Luming Jia,  Fei Zhao( )
College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China
Keywords:
Silybum marianum, Silymarin, Anti-fatigue, Exhaustion exercise
Cite this article:
Jia L, Zhao F. Evaluation of silymarin extract from Silybum marianum in mice: anti-fatigue activity. Food Science and Human Wellness, 2022, 11(4): 914-921. https://doi.org/10.1016/j.fshw.2022.03.017
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Abstract Full text About this article

Silymarin has been used for centuries for its hepatoprotective properties. The specific objective of this study was to evaluate the anti-fatigue properties of silymarin. The silymarin was administered orally at doses of 50, 100, and 200 mg/kg for 4 weeks; the fatigue level and exercise performance were evaluated using exhaustive swimming time and pole-climbing time, as well as levels of plasma lactate, ammonia, glucose, creatine kinase (CK), serum urea nitrogen (SUN), blood lactic acid (BLA), muscle glycogen (MG), and liver glycogen (LG) contents after an intensive swimming session. The results demonstrated that silymarin treatment decreased the BLA and SUN levels while increased the LG and MG levels. In addition, silymarin decreased plasma lactate and ammonia levels and CK activity after swimming test, this is related to the mechanism that increases energy storage (as glycogen) and release (as blood glucose), and decreases plasma levels of lactate, ammonia, and CK. The observation of the skeletal muscle structures of mice also confirmed that skeletal muscles became more damaged in the control group compared with the silymarin-treated mice after prolonged endurance exercise. Therefore, it is reasonable to infer that silymarin may bear potential pharmacological effects in combating fatigue.


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About this article

Evaluation of silymarin extract from Silybum marianum in mice: anti-fatigue activity

Show Author's information Luming Jia, Fei Zhao( )
College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China

Abstract

Silymarin has been used for centuries for its hepatoprotective properties. The specific objective of this study was to evaluate the anti-fatigue properties of silymarin. The silymarin was administered orally at doses of 50, 100, and 200 mg/kg for 4 weeks; the fatigue level and exercise performance were evaluated using exhaustive swimming time and pole-climbing time, as well as levels of plasma lactate, ammonia, glucose, creatine kinase (CK), serum urea nitrogen (SUN), blood lactic acid (BLA), muscle glycogen (MG), and liver glycogen (LG) contents after an intensive swimming session. The results demonstrated that silymarin treatment decreased the BLA and SUN levels while increased the LG and MG levels. In addition, silymarin decreased plasma lactate and ammonia levels and CK activity after swimming test, this is related to the mechanism that increases energy storage (as glycogen) and release (as blood glucose), and decreases plasma levels of lactate, ammonia, and CK. The observation of the skeletal muscle structures of mice also confirmed that skeletal muscles became more damaged in the control group compared with the silymarin-treated mice after prolonged endurance exercise. Therefore, it is reasonable to infer that silymarin may bear potential pharmacological effects in combating fatigue.

Keywords: Silybum marianum, Silymarin, Anti-fatigue, Exhaustion exercise

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Publication history

Received: 17 September 2020
Revised: 14 January 2021
Accepted: 14 February 2021
Published: 28 April 2022
Issue date: July 2022

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© 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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