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Food Science and Human Wellness 2022, 11(3): 711-718 https://doi.org/10.1016/j.fshw.2021.12.028
Research Article | Open Access | Issue | Published: 04 February 2022

Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model

Show Author's Information Wei Xua,b,c,  Yang Zhoua,b,c,  Ling Lina,b,c,  Dongyin Yuana,b,c,  Yingqi Penga,b,c,  Li Lid,  Wenjun Xiaoa,b,c( ),  Zhihua Gonga,b,c( )
Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China
National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China
Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Changsha 410128, China
Hunan Baojiachong Tea Farm Co. Ltd., Yiyang 413500, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Black tea, Black brick tea (with fungal growth), High blood glucose, Hypoglycemic effect
Cite this article:
Xu W, Zhou Y, Lin L, et al. Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model. Food Science and Human Wellness, 2022, 11(3): 711-718. https://doi.org/10.1016/j.fshw.2021.12.028
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Abstract Full text About this article

Dark tea (containing Eurotium cristatum) and black tea have hypoglycemic effects. The black brick tea with fungal growth is obtained from black tea by adding E. cristatum, followed by steaming, pressing, fungal growth, and drying. However, the hypoglycemic effects of black brick tea are still unexplored. Here, we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice model. Both these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and mRNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase, glycogen synthase, protein kinase B and phosphoinositide-dependent protein kinase-1 and downregulating the protein and mRNA expression of glycogen synthase kinase 3β. These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of malondialdehyde. These teas can promote blood glucose transport and absorption by upregulating the protein and mRNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and mRNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. Our study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.


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About this article

Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model

Show Author's information Wei Xua,b,c, Yang Zhoua,b,c, Ling Lina,b,c, Dongyin Yuana,b,c, Yingqi Penga,b,c, Li Lid, Wenjun Xiaoa,b,c( ), Zhihua Gonga,b,c( )
Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China
National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China
Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Changsha 410128, China
Hunan Baojiachong Tea Farm Co. Ltd., Yiyang 413500, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Dark tea (containing Eurotium cristatum) and black tea have hypoglycemic effects. The black brick tea with fungal growth is obtained from black tea by adding E. cristatum, followed by steaming, pressing, fungal growth, and drying. However, the hypoglycemic effects of black brick tea are still unexplored. Here, we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice model. Both these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and mRNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase, glycogen synthase, protein kinase B and phosphoinositide-dependent protein kinase-1 and downregulating the protein and mRNA expression of glycogen synthase kinase 3β. These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of malondialdehyde. These teas can promote blood glucose transport and absorption by upregulating the protein and mRNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and mRNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. Our study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.

Keywords: Black tea, Black brick tea (with fungal growth), High blood glucose, Hypoglycemic effect

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Publication history

Received: 06 January 2021
Revised: 16 February 2021
Accepted: 17 February 2021
Published: 04 February 2022
Issue date: May 2022

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© 2022 Beijing Academy of Food Sciences.

Acknowledgements

Acknowledgement

We would like to thank Editage for English language editing. This work was supported by The National Natural Science Foundation of China (grant number 31871804), Natural Science Foundation Project of Hunan Province, China (grant number 2020JJ4036), and the Key R & D Program of Hunan Province (2020NK2030).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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