Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases

Van-Long Truong; Woo-Sik Jeong

doi:10.1016/j.fshw.2021.12.008

Food Science and Human Wellness 2022, 11(3): 502-511 https://doi.org/10.1016/j.fshw.2021.12.008

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Open Access | Issue | Published: 04 February 2022

Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases

Show Author's Information Hide Author's Information Van-Long Truong, Woo-Sik Jeong(

)

Food and Bio-industry Research Institute, School of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea

Keywords:

Gut microbiota, Antioxidant, Anti-inflammation, Tea polyphenols, Epithelial barrier function, Inflammatory bowel diseases

Cite this article:

Truong V-L, Jeong W-S. Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases. Food Science and Human Wellness, 2022, 11(3): 502-511. https://doi.org/10.1016/j.fshw.2021.12.008

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Abstract Full text About this article

Abstract

Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants. Tea (Camellia sinensis) is particularly rich in polyphenols (e.g., catechins, theaflavins, thearubigins, gallic acid, and flavonols), which are thought to contribute to the health benefits of tea. High intake of tea polyphenols has been described to prevent and/or attenuate a variety of chronic pathological conditions like cardiovascular diseases, neurodegenerative diseases, diabetes, and cancer. This review focuses on established antioxidant and anti-inflammatory properties of tea polyphenols and underlying mechanisms of their involvement in inflammatory bowel diseases (IBD). Tea polyphenols act as efficient antioxidants by inducing an endogenous antioxidant defense system and maintaining intracellular redox homeostasis. Tea polyphenols also regulate signaling pathways such as nuclear factor-κB, activator protein 1, signal transducer and activator of transcriptions, and nuclear factor E2-related factor 2, which are associated with IBD development. Accumulating pieces of evidence have indicated that tea polyphenols enhance epithelial barrier function and improve gut microbial dysbiosis, contributing to the management of inflammatory colitis. Therefore, this study suggests that supplementation of tea polyphenols could prevent inflammatory conditions and improve the outcome of patients with IBD.

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Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases

Show Author's information Hide Author's Information Van-Long Truong, Woo-Sik Jeong(

)

Food and Bio-industry Research Institute, School of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea

Abstract

Keywords: Gut microbiota, Antioxidant, Anti-inflammation, Tea polyphenols, Epithelial barrier function, Inflammatory bowel diseases

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Received: 27 December 2020

Revised: 01 February 2021

Accepted: 01 February 2021

Published: 04 February 2022

Issue date: May 2022

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