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Food Science and Human Wellness 2021, 10(1): 87-93 https://doi.org/10.1016/j.fshw.2020.06.001
Research Article | Open Access | Issue | Published: 12 June 2020

Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice

Show Author's Information Huan Xianga( ),  Dongxiao Sun-Waterhousea,c( ),  Chun Cuia,b( )
School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China
Guangdong Weiwei Biotechnology Co., LTD, Guangzhou, 510640, Guangdong, China
School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
Keywords:
Polysaccharides, Auricularia auricula, Auricularia polytricha, Hypoglycemic effect, Oxidative stress
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Xiang H, Sun-Waterhouse D, Cui C. Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice. Food Science and Human Wellness, 2021, 10(1): 87-93. https://doi.org/10.1016/j.fshw.2020.06.001
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Abstract Full text About this article

Auricularia auricula (AA) and Auricularia polytricha (AP) are popular edible fungi. This study successfully produced hypoglycemic polysaccharides from un-smashed or smashing and sieving (through a 10-mesh sieve) AA and AP (termed as AAP/AAP-10 and APP/APP-10) via scalable processes (water extraction, ethanolic precipitation and deproteinization). This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice (body weight, fasting blood glucose, serum insulin, proinflammatory mediator and cytokines, oxidative stress-related products, antioxidant enzymes). APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose (100 mg/kg/day) likely working better. At the same dose, APP generally performed more effective than AAP, and AAP-10/APP-10 seemed slightly more beneficial than AAP/APP. One mechanism underlying these antidiabetic functions might involve the NF-κB and associated signalling pathways. AP is cheaper than AA, thereby representing a favorable source of functional polysaccharides.


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About this article

Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice

Show Author's information Huan Xianga( ), Dongxiao Sun-Waterhousea,c( ), Chun Cuia,b( )
School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China
Guangdong Weiwei Biotechnology Co., LTD, Guangzhou, 510640, Guangdong, China
School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand

Abstract

Auricularia auricula (AA) and Auricularia polytricha (AP) are popular edible fungi. This study successfully produced hypoglycemic polysaccharides from un-smashed or smashing and sieving (through a 10-mesh sieve) AA and AP (termed as AAP/AAP-10 and APP/APP-10) via scalable processes (water extraction, ethanolic precipitation and deproteinization). This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice (body weight, fasting blood glucose, serum insulin, proinflammatory mediator and cytokines, oxidative stress-related products, antioxidant enzymes). APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose (100 mg/kg/day) likely working better. At the same dose, APP generally performed more effective than AAP, and AAP-10/APP-10 seemed slightly more beneficial than AAP/APP. One mechanism underlying these antidiabetic functions might involve the NF-κB and associated signalling pathways. AP is cheaper than AA, thereby representing a favorable source of functional polysaccharides.

Keywords: Polysaccharides, Auricularia auricula, Auricularia polytricha, Hypoglycemic effect, Oxidative stress

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Publication history

Received: 16 April 2020
Revised: 31 May 2020
Accepted: 01 June 2020
Published: 12 June 2020
Issue date: January 2021

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© 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Acknowledgements

Acknowledgements

The authors are grateful for the financial support from National key Technologies R & D Program for 13th Five-year Plan (2016YFD0400803), National Natural Science Foundation of China (No. 31201416) and Science and Technology Plan of Guangdong Province (2017ZD093).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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