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Food Science and Human Wellness 2020, 9(3): 229-236 https://doi.org/10.1016/j.fshw.2020.04.012
Research Article | Open Access | Issue | Published: 16 May 2020

Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats

Show Author's Information Guang Chenga,b,§,  Zhiwei Yuea,b,§,  Liwen Wangb,  Yutaka Miyauchic,  Michiko Suzawac,  Shiming Lid,e,  Chi‐Tang Hoe,  Hui Zhaob( ),  Naiyao Chena( )
Department of Hematology and Tangshan Key Laboratory, Translational Medical Center, North China University of Science and Technology, Tangshan, Hebei 063000, China
Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China
Miyauchi Citrus Research Center, Takasaki, Gunma, Japan
Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Huanggang Normal University, Huanggang, Hubei 438000, China
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, United States

§ The equal contribution to this article.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Keywords:
Inflammation, Traumatic brain injury, Cognitive, Citrus peel, Gold lotion
Cite this article:
Cheng G, Yue Z, Wang L, et al. Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats. Food Science and Human Wellness, 2020, 9(3): 229-236. https://doi.org/10.1016/j.fshw.2020.04.012
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Abstract Full text About this article

Traumatic brain injury (TBI) is closely related to neuro-inflammatory response and causes a complex pathological process and serious consequence. In this study, we explored whether the formatted citrus peel extract gold lotion (GL) could have a therapeutic effect on rats suffered TBI. TBI rat model was prepared by the electric Cortical Contusion Impactor (eCCI) device. Prevention against TBI by GL was assessed by the behavioral, organizational of rats and the molecular markers in the brain injury area. The results showed that GL could reduce nerve damage and neurological dysfunction. The mechanisms probably due to that GL could not only reduce the associated damage markers including GFAP, OX-42, TNF-α, COX-2, NF-κB and TLR4 but also promote the expression of VEGF which is responsible for protecting neuronal cells in the injury area. These findings revealed that GL could be a promising preparation for TBI prevention.


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About this article

Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats

Show Author's information Guang Chenga,b,§, Zhiwei Yuea,b,§, Liwen Wangb, Yutaka Miyauchic, Michiko Suzawac, Shiming Lid,e, Chi‐Tang Hoe, Hui Zhaob( ), Naiyao Chena( )
Department of Hematology and Tangshan Key Laboratory, Translational Medical Center, North China University of Science and Technology, Tangshan, Hebei 063000, China
Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China
Miyauchi Citrus Research Center, Takasaki, Gunma, Japan
Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Huanggang Normal University, Huanggang, Hubei 438000, China
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, United States

§ The equal contribution to this article.Peer review under responsibility of KeAi Communications Co., Ltd.]]>

Abstract

Traumatic brain injury (TBI) is closely related to neuro-inflammatory response and causes a complex pathological process and serious consequence. In this study, we explored whether the formatted citrus peel extract gold lotion (GL) could have a therapeutic effect on rats suffered TBI. TBI rat model was prepared by the electric Cortical Contusion Impactor (eCCI) device. Prevention against TBI by GL was assessed by the behavioral, organizational of rats and the molecular markers in the brain injury area. The results showed that GL could reduce nerve damage and neurological dysfunction. The mechanisms probably due to that GL could not only reduce the associated damage markers including GFAP, OX-42, TNF-α, COX-2, NF-κB and TLR4 but also promote the expression of VEGF which is responsible for protecting neuronal cells in the injury area. These findings revealed that GL could be a promising preparation for TBI prevention.

Keywords: Inflammation, Traumatic brain injury, Cognitive, Citrus peel, Gold lotion

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Received: 30 September 2019
Revised: 27 February 2020
Accepted: 27 April 2020
Published: 16 May 2020
Issue date: September 2020

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