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Food Science and Human Wellness 2020, 9(1): 1-7 https://doi.org/10.1016/j.fshw.2020.01.001
Review Article | Open Access | Issue | Published: 07 January 2020

Dietary peptides in aging: Evidence and prospects

Show Author's Information Khushwant S. Bhullara,b,  Jianping Wua( )
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
Department of Pharmacology, University of Alberta, Edmonton, AB, Canada

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Anti-aging, Dietary peptides, Aging biomarkers
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Bhullar KS, Wu J. Dietary peptides in aging: Evidence and prospects. Food Science and Human Wellness, 2020, 9(1): 1-7. https://doi.org/10.1016/j.fshw.2020.01.001
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Abstract Full text About this article

With improvements in healthcare and lifestyle, the proportion of the aging population is rising steadily across the world. Many physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial disturbances. Thus, there is an urge to better develop dietary or medicinal interventions targeting the mechanisms underlying aging and aging-related diseases. Many reports indicate that in geroscience, dietary interventions such as bioactive peptides to slow aging are a matter of 'when' rather than 'if'. Leading targets for peptides include the metabolic-mitochondrial pathway accompanied by improved nutrient sensing. Modulation of these pathways diminish aging biomarkers in various model organisms and confers protection against a growing list of age-related pathophysiologies. Food derived bioactive peptides are characterized modulators of these pathways, while some verified in vivo and even clinically approved, and numerous others are under development. This brief review focuses on the latest scientific advances in understanding the anti-aging ability of bioactive peptides as well as delineates the possible future directions in this process.


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About this article

Dietary peptides in aging: Evidence and prospects

Show Author's information Khushwant S. Bhullara,b, Jianping Wua( )
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
Department of Pharmacology, University of Alberta, Edmonton, AB, Canada

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

With improvements in healthcare and lifestyle, the proportion of the aging population is rising steadily across the world. Many physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial disturbances. Thus, there is an urge to better develop dietary or medicinal interventions targeting the mechanisms underlying aging and aging-related diseases. Many reports indicate that in geroscience, dietary interventions such as bioactive peptides to slow aging are a matter of 'when' rather than 'if'. Leading targets for peptides include the metabolic-mitochondrial pathway accompanied by improved nutrient sensing. Modulation of these pathways diminish aging biomarkers in various model organisms and confers protection against a growing list of age-related pathophysiologies. Food derived bioactive peptides are characterized modulators of these pathways, while some verified in vivo and even clinically approved, and numerous others are under development. This brief review focuses on the latest scientific advances in understanding the anti-aging ability of bioactive peptides as well as delineates the possible future directions in this process.

Keywords: Anti-aging, Dietary peptides, Aging biomarkers

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Acknowledgements
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Publication history

Received: 03 November 2019
Accepted: 06 January 2020
Published: 07 January 2020
Issue date: March 2020

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© 2020 "Society information".

Acknowledgements

Acknowledgements

This work is funded by Natural Sciences and Engineering Research Council of Canada (NSERC).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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