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Food Science and Human Wellness 2019, 8(4): 315-319 https://doi.org/10.1016/j.fshw.2019.11.005
Review Article | Open Access | Issue | Published: 28 November 2019

Application of natural β-glucans as biocompatible functional nanomaterials

Show Author's Information Xiaojie Li,,  Peter Chi Keung Cheung( )
Food and Nutritional Sciences, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Keywords:
Biocompatibility, Nanohybrids, β-Glucans, Biopharmaceuticals
Cite this article:
Li X, Cheung PCK. Application of natural β-glucans as biocompatible functional nanomaterials. Food Science and Human Wellness, 2019, 8(4): 315-319. https://doi.org/10.1016/j.fshw.2019.11.005
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Abstract Full text About this article

Naturally-occurring β-glucans are mostly investigated for their antitumor activity and immunomodulatory property. They have been widely regarded as a natural source for functional foods and pharmaceuticals. However, the physico-chemically stable and biocompatible properties of β-glucans are rarely explored as a coating material for nanomaterials to overcome the problems of aggregation and cytotoxicity. This article reviews on the exploration of β-glucans, in particular those derived from mushrooms, as a natural coating material to modify the surface properties of bioactive substances as a relatively simple and cost-effective strategy to produce stable and biocompatible nanohybrids used for biopharmaceutical use. It is envisaged that such β-glucan-based coating method will provide new opportunities to design biocompatible functional nanomaterials for wider clinical applications.


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About this article

Application of natural β-glucans as biocompatible functional nanomaterials

Show Author's information Xiaojie Li,, Peter Chi Keung Cheung( )
Food and Nutritional Sciences, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China

Peer review under responsibility of KeAi Communications Co., Ltd.

Abstract

Naturally-occurring β-glucans are mostly investigated for their antitumor activity and immunomodulatory property. They have been widely regarded as a natural source for functional foods and pharmaceuticals. However, the physico-chemically stable and biocompatible properties of β-glucans are rarely explored as a coating material for nanomaterials to overcome the problems of aggregation and cytotoxicity. This article reviews on the exploration of β-glucans, in particular those derived from mushrooms, as a natural coating material to modify the surface properties of bioactive substances as a relatively simple and cost-effective strategy to produce stable and biocompatible nanohybrids used for biopharmaceutical use. It is envisaged that such β-glucan-based coating method will provide new opportunities to design biocompatible functional nanomaterials for wider clinical applications.

Keywords: Biocompatibility, Nanohybrids, β-Glucans, Biopharmaceuticals

References(48)

[1]

H. Stier, V. Ebbeskotte, J. Gruenwald, Immune-modulatory effects of dietary yeast beta-1,3/1,6-D-glucan, Nutr. J. 13 (2014) 38.
DOI Google Scholar
[2]

A. Synytsya, M. Novak, Structural analysis of glucans, Ann. Transl. Med. 2 (2) (2014) 17.
Google Scholar
[3]

S. Shivakumar, S.V.N. Vijayendra, Production of exopolysaccharides by Agrobacterium sp. CFR-24 using coconut water - a byproduct of food industry, Lett. Appl. Microbiol. 42 (5) (2006) 477-482.
DOI Google Scholar
[4]

Y.F. Wang, M. Zhang, D. Ruan, et al., Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of Poria cocos, Carbohydr. Res. 339 (2) (2004) 327-334.
DOI Google Scholar
[5]

M.J. Edney, B.A. Marchylo, A.W. Macgregor, Structure of total barley beta-glucan, J. Inst. Brew. 97 (1) (1991) 39-44.
DOI Google Scholar
[6]

A. Ahmad, F.M. Anjum, T. Zahoor, et al., Beta glucan: a valuable functional ingredient in foods, Crit. Rev. Food Sci. Nutr. 52 (1-3) (2012) 201-212.
DOI Google Scholar
[7]

A.O. Chizhov, A. Dell, H.R. Morris, et al., Structural analysis of laminarans by MALDI and FAB mass spectrometry, Carbohydr. Res. 310 (3) (1998) 203-210.
DOI Google Scholar
[8]

T. Yanaki, K. Tabata, T. Kojima, Melting behavior of a triple helical polysaccharide schizophyllan in aqueous-solution, Carbohydr. Polym. 5 (4) (1985) 275-283.
DOI Google Scholar
[9]

M.W. Breedveld, K.J. Miller, Cyclic beta-glucans of members of the family rhizobiaceae, Microbiol. Rev. 58 (2) (1994) 145-161.
DOI Google Scholar
[10]

Y.Z. Tao, L. Zhang, Determination of molecular size and shape of hyperbranched polysaccharide in solution, Biopolymers 83 (4) (2006) 414-423.
DOI Google Scholar
[11]

J.A. Bohn, J.N. BeMiller, (1→3)-Beta-D-glucans as biological response modifiers: a review of structure-functional activity relationships, Carbohydr. Polym. 28 (1) (1995) 3-14.
DOI Google Scholar
[12]

Y. Murata, T. Shimamura, T. Tagami, et al., The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content, Int. Immunopharmacol. 2 (5) (2002) 673-689.
DOI Google Scholar
[13]

J.P. Fruehauf, G.D. Bonnard, R.B. Herberman, The effect of lentinan on production of interleukin-1 by human-monocytes, Immunopharmacology 5 (1) (1982) 65-74.
DOI Google Scholar
[14]

J. Yan, H.L. Zong, A.G. Shen, et al., The beta-(1→6)-branched beta-(1→3) glucohexaose and its analogues containing an alpha-(1→3)-linked bond have similar stimulatory effects on the mouse spleen as Lentinan, Int. Immunopharmacol. 3 (13–14) (2003) 1861-1871.
DOI Google Scholar
[15]

K. Oba, M. Kobayashi, T. Matsui, et al., Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer, Anticancer Res. 29 (7) (2009) 2739-2745.
Google Scholar
[16]

M. Kozarski, A. Klaus, M. Niksic, et al., Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus, Food Chem. 129 (4) (2011) 1667-1675.
DOI Google Scholar
[17]

K. Okamura, M. Suzuki, T. Chihara, et al., Clinical evaluation of Schizophyllan combined with irradiation in patients with cervical cancer: a randomized controlled study, Cancer 58 (4) (1986) 865-872.
DOI Google Scholar
[18]

L.L. Yue, H.X. Cui, C.C. Li, et al., A polysaccharide from Agaricus blazei attenuates tumor cell adhesion via inhibiting E-selectin expression, Carbohydr. Polym. 88 (4) (2012) 1326-1333.
DOI Google Scholar
[19]

Y. Cao, Y. Sun, S.W. Zou, et al., Yeast beta-glucan suppresses the chronic inflammation and improves the microenvironment in adipose tissues of ob/ob mice, J. Agric. Food Chem. 66 (3) (2018) 621-629.
DOI Google Scholar
[20]
FDA, Final Rule for Food Labelling: Health Claims: Oats and Coronary Heart Disease, Federal Regulations 62 (1997).
[21]

J. Hallfrisch, K.M. Behall, Improvement in insulin and glucose responses related to grains, Cereal Foods World 45 (2) (2000) 66-69.
Google Scholar
[22]

J. Hallfrisch, D.J. Scholfield, K.M. Behall, Physiological responses of men and women to barley and oat extracts (Nu-trimX). Ⅱ. Comparison of glucose and insulin responses, Cereal Chem. 80 (1) (2003) 80-83.
DOI Google Scholar
[23]
N. Benkeblia, Polysaccharides Natural Fibers in Food and Nutrition, CRC Press, Boca Raton, FL (2014).
[24]

I. Giavasis, Bioactive fungal polysaccharides as potential functional ingredients in food and nutraceuticals, Curr. Opin. Biotechnol. 26 (2014) 162-173.
DOI Google Scholar
[25]

F.M.N.A. Aida, M. Shuhaimi, M. Yazid, et al., Mushroom as a potential source of prebiotics: a review, Trends Food Sci. Technol. 20 (11–12) (2009) 567-575.
DOI Google Scholar
[26]

J.Y. Zhao, P.C.K. Cheung, Fermentation of beta-glucans derived from different sources by bifidobacteria: evaluation of their bifidogenic effect, J. Agric. Food Chem. 59 (11) (2011) 5986-5992.
DOI Google Scholar
[27]

T. Hasegawa, S. Haraguchi, M. Numata, et al., Schizophyllan can act as a one-dimensional host to construct poly(diacetylene) nanofibers, Chem. Lett. 34 (1) (2005) 40-41.
DOI Google Scholar
[28]

I.K. Sen, K. Maity, S.S. Islam, Green synthesis of gold nanoparticles using a glucan of an edible mushroom and study of catalytic activity, Carbohydr. Polym. 91 (2) (2013) 518-528.
DOI Google Scholar
[29]

E. Blanco, H. Shen, M. Ferrari, Principles of nanoparticle design for overcoming biological barriers to drug delivery, Nat. Biotechnol. 33 (9) (2015) 941-951.
DOI Google Scholar
[30]

H.R. de Barrosa, L. Piovan, G.L. Sassaki, et al., Surface interactions of gold nanorods and polysaccharides: from clusters to individual nanoparticles, Carbohydr. Polym. 152 (2016) 479-486.
DOI Google Scholar
[31]

A.J. McGrath, Y.H. Chien, S. Cheong, et al., Gold over branched palladium nanostructures for photothermal cancer therapy, ACS Nano 9 (12) (2015) 12283-12291.
DOI Google Scholar
[32]

P.H. Qiu, M.Y. Yang, X.W. Qu, et al., Tuning photothermal properties of gold nanodendrites for in vivo cancer therapy within a wide near infrared range by simply controlling their degree of branching, Biomaterials 104 (2016) 138-144.
DOI Google Scholar
[33]

T.C.Y. Leung, C.K. Wong, Y. Xie, Green synthesis of silver nanoparticles using biopolymers, carboxymethylated-curdlan and fucoidan, Mater. Chem. Phys. 121 (3) (2010) 402-405.
DOI Google Scholar
[34]

Y.F. Zhang, J.G. Wang, L.N. Zhang, Creation of highly stable selenium nanoparticles capped with hyperbranched polysaccharide in water, Langmuir 26 (22) (2010) 17617-17623.
DOI Google Scholar
[35]

Q. Luan, W.J. Zhou, H. Zhang, et al., Cellulose-based composite macrogels from cellulose fiber and cellulose nanofiber as intestine delivery vehicles for probiotics, J. Agric. Food Chem. 66 (1) (2018) 339-345.
DOI Google Scholar
[36]

E.R. Soto, A.C. Caras, L.C. Kut, et al., Glucan particles for macrophage targeted delivery of nanoparticles, J. Drug Deliv. 2012 (2012) 143524.
DOI Google Scholar
[37]

A. Querejeta-Fernandez, G. Chauve, M. Methot, et al., Chiral plasmonic films formed by gold nanorods and cellulose nanocrystals, J. Am. Chem. Soc. 136 (12) (2014) 4788-4793.
DOI Google Scholar
[38]

J.A. Okhuoya, J.E. Etugo, Studies of the cultivation of Pleurotus tuberregium (FR) sing. An edible mushroom, Bioresour. Technol. 44 (1) (1993) 1-3.
DOI Google Scholar
[39]

B.A. Oso, Pleurotus tuber-regium from Nigeria, Mycologia 69 (2) (1977) 271-279.
DOI Google Scholar
[40]

H.J. Willetts, S. Bullock, Developmental biology of sclerotia, Mycol. Res. 96 (1992) 801-816.
DOI Google Scholar
[41]

M. Zhang, P.C.K. Cheung, V.E.C. Ooi, et al., Evaluation of sulfated fungal beta-glucans from the sclerotium of Pleurotus tuber-regium as a potential water-soluble anti-viral agent, Carbohydr. Res. 339 (13) (2004) 2297-2301.
DOI Google Scholar
[42]

K.H. Wong, C.K.M. Lai, P.C.K. Cheung, Immunomodulatory activities of mushroom sclerotial polysaccharides, Food Hydrocoll. 25 (2) (2011) 150-158.
DOI Google Scholar
[43]

M. Zhang, P.C.K. Cheung, L. Zhang, Evaluation of mushroom dietary fiber (nonstarch polysaccharides) from sclerotia of Pleurotus tuber-regium (Fries) Singer as a potential antitumor agent, J. Agric. Food Chem. 49 (10) (2001) 5059-5062.
DOI Google Scholar
[44]

L. Chen, B.B. Zhang, J.L. Chen, et al., Cell wall structure of mushroom sclerotium (Pleurotus tuber-regium): part 2. Fine structure of a novel alkali-soluble hyper-branched cell wall polysaccharide, Food Hydrocoll. 38 (2014) 48-55.
DOI Google Scholar
[45]

X.J. Li, J.J. Zhou, C.R. Liu, et al., Stable and biocompatible mushroom null-glucan modified gold nanorods for cancer photothermal therapy, J. Agric. Food Chem. 65 (2017) 9529-9536.
DOI Google Scholar
[46]

X.J. Li, J.J. Zhou, X.N. Dong, et al., In vitro and in vivo photothermal cancer therapeutic effects of gold nanorods modified with mushroom β-glucan, J. Agric. Food Chem. 66 (2018) 4091-4098.
DOI Google Scholar
[47]

J.-E. Park, M. Kim, J.-H. Hwang, et al., Golden opportunities: plasmonic gold nanostructures for biomedical applications based on the second near-infrared window, Small Methods 1 (3) (2017) 1600032.
DOI Google Scholar
[48]

X. Yang, M.X. Yang, B. Pang, et al., Gold nanomaterials at work in biomedicine, Chem. Rev. 115 (19) (2015) 10410-10488.
DOI Google Scholar
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Publication history

Received: 27 September 2019
Revised: 16 November 2019
Accepted: 18 November 2019
Published: 28 November 2019
Issue date: December 2019

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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