Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats

Balan Rajan; Rajendran Ravikumar; Thandavamoorthy Premkumar; Thiruvengadam Devaki

doi:10.1016/j.fshw.2015.04.002

Food Science and Human Wellness 2015, 4(2): 66-74 https://doi.org/10.1016/j.fshw.2015.04.002

Research Article |

Open Access | Issue | Published: 23 May 2015

Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats

Show Author's Information Hide Author's Information Balan Rajan^¹, Rajendran Ravikumar^¹, Thandavamoorthy Premkumar, Thiruvengadam Devaki(

)

Department of Biochemistry, Guindy Campus, University of Madras, Chennai 600025, TN, India

¹ These authors contributed equally to this work.

Peer review under responsibility of Beijing Academy of Food Sciences.

Keywords:

Liver damage, Antioxidants, Carvacrol, DEN, Hepatotoxicity, Marker enzyme

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Rajan B, Ravikumar R, Premkumar T, et al. Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats. Food Science and Human Wellness, 2015, 4(2): 66-74. https://doi.org/10.1016/j.fshw.2015.04.002

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Abstract

Carvacrol is a main constituent in the essential oils of countless aromatic plants including Origanum Vulgare and Thymus vulgari, which has been assessed for substantial pharmacological properties. In recent years, notable research has been embarked on to establish the biological actions of Carvacrol for its promising use in clinical applications. The present study is an attempt to reveal the protective role of Carvacrol against N-Nitrosodiethylamine (DEN) induced hepatic injury in male Wistar albino rats. DEN is an egregious toxin, present in numerous environmental factors, which enhances chemical driven liver damage by inducing oxidative stress and cellular injury. Administration of DEN (200 mg/kg bodyweight, I.P) to rats results in elevated marker enzymes (in both serum and tissue). Carvacrol (15 mg/kg body weight) suppressed the elevation of marker enzymes (in both serum and tissue) and augmented the antioxidants levels. The hoisted activities of Phase Ⅰ enzymes and inferior activities of Phase Ⅱ enzymes were observed in DEN-administered animals, whereas Carvacrol treated animals showed improved near normal activity. Histological observations also support the protective role of Carvacrol against DEN induced liver damage. Final outcome from our findings intimate that Carvacrol might be beneficial in attenuating toxin induced liver damage.

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Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats

Show Author's information Hide Author's Information Balan Rajan^¹, Rajendran Ravikumar^¹, Thandavamoorthy Premkumar, Thiruvengadam Devaki(

)

Department of Biochemistry, Guindy Campus, University of Madras, Chennai 600025, TN, India

¹ These authors contributed equally to this work.

Peer review under responsibility of Beijing Academy of Food Sciences.

Abstract

Keywords: Liver damage, Antioxidants, Carvacrol, DEN, Hepatotoxicity, Marker enzyme

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Publication history

Received: 02 January 2015

Revised: 27 April 2015

Accepted: 30 April 2015

Published: 23 May 2015

Issue date: June 2015

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Acknowledgements

The authors, Rajan Balan and Premkumar Thandavamoorthy is thankful to the Indian Council of Medical Research (ICMR), Grant no: 45/38/2013 and Grant no: 3/2/2/221/13, New Delhi, Government of India for the financial support in the form of Senior Research Fellowship (SRF).