Hepatoprotective effect of leaf extracts from <i>Citrus hystrix</i> and <i>C. maxima</i> against paracetamol induced liver injury in rats

Arumugam Abirami; Gunasekaran Nagarani; Perumal Siddhuraju

doi:10.1016/j.fshw.2015.02.002

Food Science and Human Wellness 2015, 4(1): 35-41 https://doi.org/10.1016/j.fshw.2015.02.002

Research Article |

Open Access | Issue | Published: 11 March 2015

Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats

Show Author's Information Hide Author's Information Arumugam Abirami, Gunasekaran Nagarani, Perumal Siddhuraju(

)

Bioresource Technology Lab, School of Life Sciences, Department of Environmental Sciences, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India

Peer review under responsibility of Beijing Academy of Food Sciences.

Keywords:

Silymarin, Hepatoprotection, Citrus hystrix, Citrus maxima, Paracetamol

Cite this article:

Abirami A, Nagarani G, Siddhuraju P. Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats. Food Science and Human Wellness, 2015, 4(1): 35-41. https://doi.org/10.1016/j.fshw.2015.02.002

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Abstract Full text About this article

Abstract

The present investigation is aimed to evaluate the hepatoprotective effects of Citrus hystrix and Citrus maxima (Red and White variety) methanolic leaf extracts on paracetamol induced toxicity. Leaf extracts were given in the dose of 200mg/kg body weight for 7 days and toxicity was induced by paracetamol (2g/kg) on day 5. Silymarin (100mg/kg body weight) was used as reference standard. On the 7th day animals were sacrificed and liver function markers (ALT, AST, ALP), total bilirubin and total protein in blood serums and hepatic antioxidants (SOD, CAT, GSH and GPx) in liver homogenate were estimated. The leaf extracts restored the liver function markers and hepatic antioxidants to the normal level than elevated levels noticed on paracetamol control at P < 0.001. Reversal of hepatoarchitecture has also been registered. The present study shows that C. hystrix and C. maxima leaf extracts possess hepatoprotective action against paracetamol induced hepatotoxicity.

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Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats

Show Author's information Hide Author's Information Arumugam Abirami, Gunasekaran Nagarani, Perumal Siddhuraju(

)

Bioresource Technology Lab, School of Life Sciences, Department of Environmental Sciences, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India

Peer review under responsibility of Beijing Academy of Food Sciences.

Abstract

Keywords: Silymarin, Hepatoprotection, Citrus hystrix, Citrus maxima, Paracetamol

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Publication history

Acknowledgements

Publication history

Received: 12 November 2014

Revised: 20 January 2015

Accepted: 23 February 2015

Published: 11 March 2015

Issue date: March 2015

Copyright

Acknowledgements

The authors would like to thank Dr. T. Sivakumar, Principal, Nandha College of Pharmacy and Research Institute, Erode, TN, India for necessary permission to carry out the study and Dr. S. Sengottuvelu, Head, Department of Pharmacology, and Mrs. V. Lalitha, Department of Pharmacology, Nandha College of Pharmacy and Research Institute for their support and suggestions.