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Food Science and Human Wellness 2014, 3(3-4): 127-135 https://doi.org/10.1016/j.fshw.2014.12.002
Research Article | Open Access | Issue | Published: 05 January 2015

Bone morphogenetic proteins: Relationship between molecular structure and their osteogenic activity

Show Author's Information Jian Yang,  Pujie Shi,  Maolin Tu,  Yun Wang,  Meng Liu,  Fengjiao Fan,  Ming Du( )
School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, PR China

Peer review under responsibility of Beijing Academy of Food Sciences.

Keywords:
Interaction, Structure, Bone morphogenetic proteins, Osteogenic activity, Signal pathways
Cite this article:
Yang J, Shi P, Tu M, et al. Bone morphogenetic proteins: Relationship between molecular structure and their osteogenic activity. Food Science and Human Wellness, 2014, 3(3-4): 127-135. https://doi.org/10.1016/j.fshw.2014.12.002
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Abstract Full text About this article

Bone morphogenetic proteins (BMPs) are a family of potent, multifunctional growth factors belonging to transforming growth factor-β (TGF-β). They are highly conservative in structures. Over 20 members of BMPs with varying functions such as embryogenesis, skeletal formation, hematopoiesis and neurogenesis have been identified in human body. BMPs are unique growth factors that can induce the formation of bone tissue individually. BMPs can induce the differentiation of bone marrow mesenchymal stem cells into osteoblastic lineage and promote the proliferation of osteoblasts and chondrocytes. BMPs stimulate the target cells by specific membrane-bound receptors and signal transduced through mothers against decapentaplegic (Smads) and mitogen activated protein kinase (MAPK) pathways. It has been demonstrated that BMP-2, BMP-4, BMP-6, BMP-7, and BMP-9 play an important role in bone formation. This article focuses on the molecular characterization of BMPs family members, mechanism of osteogenesis promotion, related signal pathways of osteogenic function, relationships between structure and osteogenetic activity, and the interactions among family members at bone formation.


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About this article

Bone morphogenetic proteins: Relationship between molecular structure and their osteogenic activity

Show Author's information Jian Yang, Pujie Shi, Maolin Tu, Yun Wang, Meng Liu, Fengjiao Fan, Ming Du( )
School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, PR China

Peer review under responsibility of Beijing Academy of Food Sciences.

Abstract

Bone morphogenetic proteins (BMPs) are a family of potent, multifunctional growth factors belonging to transforming growth factor-β (TGF-β). They are highly conservative in structures. Over 20 members of BMPs with varying functions such as embryogenesis, skeletal formation, hematopoiesis and neurogenesis have been identified in human body. BMPs are unique growth factors that can induce the formation of bone tissue individually. BMPs can induce the differentiation of bone marrow mesenchymal stem cells into osteoblastic lineage and promote the proliferation of osteoblasts and chondrocytes. BMPs stimulate the target cells by specific membrane-bound receptors and signal transduced through mothers against decapentaplegic (Smads) and mitogen activated protein kinase (MAPK) pathways. It has been demonstrated that BMP-2, BMP-4, BMP-6, BMP-7, and BMP-9 play an important role in bone formation. This article focuses on the molecular characterization of BMPs family members, mechanism of osteogenesis promotion, related signal pathways of osteogenic function, relationships between structure and osteogenetic activity, and the interactions among family members at bone formation.

Keywords: Interaction, Structure, Bone morphogenetic proteins, Osteogenic activity, Signal pathways

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Received: 05 December 2014
Accepted: 26 December 2014
Published: 05 January 2015
Issue date: December 2014

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© 2015 Beijing Academy of Food Sciences.

Acknowledgements

Acknowledgements

This work was supported by National Natural Science Foundation Funding (31101316; 31371805), Program for New Century Excellent Talents in University of Ministry of Education of China (NCET-11-0796) and Heilongjiang Province Postdoctoral Science Foundation.

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