AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Tsinghua Science and Technology Article
PDF (286.3 KB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline

Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain

Zhidong LI1, Weiwei WANG2, Fangfang ZHOU2, Xia GAO1, Gaonong PENG3, Huaxi XU2, Ye-Guang CHEN1( )
State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
School of Life Sciences, Xiamen University, Xiamen 361005, China
Lean Hospital of Traditional Chinese Medicine, Lean, Jiangxi 344300, China
Show Author Information

Abstract

Amyloid precursor protein (APP) plays a critical role in the formation of Alzheimer’s disease (AD). The intracellular domain APP (AID) was suggested to cause neurotoxicity in the nucleus. To investigate the functions AID, yeast two-hybrid screening was performed to identify the proteins which interact with AID. The human brain cDNA library was screened using pGBKT7-AID as a bait, and several positive clones were identified. One of them encodes a part of the human stathmin-like 2 protein (STMN2). The interaction between STMN2 and APP implies that STMN2 may have an important function in APP-mediated AD formation.

Keywords

Alzheimer's disease (AD)amyloid precursor protein (APP)stathminstathmin-like 2 protein (STMN2)yeast two-hybrid

References

【1】
【1】
 
 
Crossref Google Scholar
Tsinghua Science and Technology
Volume 10 Issue 4,
August 2005
Pages 484-488
DOI: 10.1016/S1007-0214(05)70104-8

{{item.num}}

Comments on this article

Go to comment

< Back to all reports

Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

Review Comment

Cite this Report
Close
Close
Cite this article:
LI Z, WANG W, ZHOU F, et al. Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain. Tsinghua Science and Technology, 2005, 10(4): 484-488. https://doi.org/10.1016/S1007-0214(05)70104-8

1

Views

0

Downloads

0

Crossref

N/A

Web of Science

0

Scopus

0

CSCD
Received: 09 December 2004
Published: 01 August 2005
© Tsinghua University Press 2005