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Review | Open Access

Recent Endeavors on Molecular Imaging for Mapping Metals in Biology

Jing Gao1, Yuncong Chen1,2( ), Zijian Guo1,2, Weijiang He1( )
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering Nanjing University 210023 Nanjing China
Chemistry and Biomedicine Innovation Center Nanjing University 210023 Nanjing China
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Abstract

Transition metals such as zinc, copper and iron play vital roles in maintaining physiological functions and homeostasis of living systems. Molecular imaging, including two-photon imaging (TPI), bioluminescence imaging (BLI) and photoacoustic imaging (PAI), could act as non-invasive toolkits for capturing dynamic events in living cells, tissues and whole animals. Herein, we review the recent progress in the development of molecular probes for essential transition metals and their biological applications. We emphasize the contributions of metallostasis to health and disease, and discuss the future research directions about how to harness the great potential of metal sensors.

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Keywords

Molecular imagingZincCopperIron

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Biophysics Reports
Volume 6 Issue 5,
October 2020
Pages 159-178
DOI: 10.1007/s41048-020-00118-7

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Cite this article:
Gao J, Chen Y, Guo Z, et al. Recent Endeavors on Molecular Imaging for Mapping Metals in Biology. Biophysics Reports, 2020, 6(5): 159-178. https://doi.org/10.1007/s41048-020-00118-7

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Received: 02 June 2020
Accepted: 02 August 2020
Published: 04 October 2020
© The Author(s) 2020

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