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Biophysics Reports 2020, 6(5): 193-210 https://doi.org/10.1007/s41048-020-00117-8
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Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy

Show Author's Information Yingsi Xie1,3,,  Ruslan G. Tuguntaev1,,  Cong Mao1,  Haoting Chen1,  Ying Tao1,  Shixiang Wang4( ),  Bin Yang2( ),  Weisheng Guo1( )
Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
The Sixth Affiliated Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China
Université Paris 13, 99 avenue Jean Baptiste Clément, 93430 Villetaneuse, France
Department of Cardiovascular Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China

Yingsi Xie and Ruslan G. Tuguntaev contributed equally to this work.

Keywords:
Drug delivery systems, Nanotechnology, Rheumatoid arthritis, Stimuli-responsive polymers
Cite this article:
Xie Y, Tuguntaev RG, Mao C, et al. Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy. Biophysics Reports, 2020, 6(5): 193-210. https://doi.org/10.1007/s41048-020-00117-8
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Abstract Full text About this article

Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.


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About this article

Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy

Show Author's information Yingsi Xie1,3,, Ruslan G. Tuguntaev1,, Cong Mao1, Haoting Chen1, Ying Tao1, Shixiang Wang4( ), Bin Yang2( ), Weisheng Guo1( )
Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
The Sixth Affiliated Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China
Université Paris 13, 99 avenue Jean Baptiste Clément, 93430 Villetaneuse, France
Department of Cardiovascular Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China

Yingsi Xie and Ruslan G. Tuguntaev contributed equally to this work.

Abstract

Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.

Keywords: Drug delivery systems, Nanotechnology, Rheumatoid arthritis, Stimuli-responsive polymers

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Publication history

Received: 01 June 2020
Accepted: 15 July 2020
Published: 06 October 2020
Issue date: October 2020

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© The Author(s) 2020

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The authors thank the financial support under the National Natural Science Foundation of China (31971302 and 51903062), Natural Science Foundation of Guangdong Province of China (2019A1515011597 and 2018A030313588) and Project of Educational Commission of Guangdong Province of China (2017KQNCX163).

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