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Review | Open Access

Epigenetic regulation of covalently closed circular DNA minichromosome in hepatitis B virus infection

Zhaoning Wang1,2, Weiwei Wang2, Lanfeng Wang2( )
School of Life Sciences, Shanghai University, Shanghai 200444, China
The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
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Abstract

Hepatitis B is caused by hepatitis B virus (HBV), and persistent HBV infection is a global public health problem, with 257 million people as HBV chronic carriers. Viral covalently closed circular DNA (cccDNA) is a key factor to establish persistent infection in infected hepatocytes. Current antiviral therapies have no direct impact on pre-existing cccDNA reservoir, which can be assembled into minichromosome by hijacking host factors. Understanding the mechanisms of epigenetic regulation in cccDNA minichromosome is crucial to develop new therapy on cccDNA, an attractive target for HBV cure. This review summarizes the current advances in epigenetic regulation of cccDNA minichromosome, which might provide clues to novel druggable targets to cure hepatitis B by either silencing or eliminating cccDNA reservoir.

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Keywords

HBVcccDNAMinichromosomeEpigenetic regulation

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Biophysics Reports
Volume 6 Issue 4,
August 2020
Pages 115-126
DOI: 10.1007/s41048-020-00112-z

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Cite this article:
Wang Z, Wang W, Wang L. Epigenetic regulation of covalently closed circular DNA minichromosome in hepatitis B virus infection. Biophysics Reports, 2020, 6(4): 115-126. https://doi.org/10.1007/s41048-020-00112-z

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Received: 17 April 2020
Accepted: 25 May 2020
Published: 25 July 2020
© The Author(s) 2020

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