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Opinion | Open Access

Proton transfer during class-A GPCR activation: do the CWxP motif and the membrane potential act in concert?

Xuejun C. Zhang1,2( ), Ye Zhou1,2, Can Cao1
National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
University of Chinese Academy of Sciences, Beijing 100049, China
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G Protein-coupled Receptors (GPCR)GPCR ActivationCWxP MotifMiddle CavityCommon Activation Mechanism

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Biophysics Reports
Volume 4 Issue 3,
June 2018
Pages 115-122
DOI: 10.1007/s41048-018-0056-0

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Zhang XC, Zhou Y, Cao C. Proton transfer during class-A GPCR activation: do the CWxP motif and the membrane potential act in concert?. Biophysics Reports, 2018, 4(3): 115-122. https://doi.org/10.1007/s41048-018-0056-0

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Received: 19 March 2018
Accepted: 10 April 2018
Published: 12 June 2018
© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.