AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Biophysics Reports Article
PDF (1.5 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans

Jiajun Fu1,2, Haining Zhang1,3, Wenming Huang1,3, Xinyu Zhu1,3, Yi Sheng1,3, Eli Song1( ), Tao Xu1,2,3( )
National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Show Author Information

Abstract

Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gαi/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding suppression. TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior.

Graphical Abstract

Keywords

C. elegans TYRA-2 receptorAIM interneuronsPeripheral feeding regulationTyramine

References

【1】
【1】
 
 
Crossref Google Scholar
Biophysics Reports
Volume 4 Issue 1,
February 2018
Pages 17-24
DOI: 10.1007/s41048-018-0046-2

{{item.num}}

Comments on this article

Go to comment

< Back to all reports

Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

Review Comment

Cite this Report
Close
Close
Cite this article:
Fu J, Zhang H, Huang W, et al. AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans. Biophysics Reports, 2018, 4(1): 17-24. https://doi.org/10.1007/s41048-018-0046-2

835

Views

46

Downloads

7

Crossref

0

Scopus

1

CSCD
Received: 12 May 2017
Accepted: 23 May 2017
Published: 05 March 2018
© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.