Stable oral lubrication enhancer obtained from thiolated polyethylene glycol and mucin

Xiaoyan HE; Pravin SMART; Mohamad TAUFIQURRAKHMAN; Chun WANG; Michael BRYANT

doi:10.1007/s40544-022-0629-2

Friction 2023, 11(4): 617-634 https://doi.org/10.1007/s40544-022-0629-2

Research Article |

Open Access | Issue | Published: 16 July 2022

Stable oral lubrication enhancer obtained from thiolated polyethylene glycol and mucin

Show Author's Information Hide Author's Information Xiaoyan HE^{¹^,²}, Pravin SMART^¹, Mohamad TAUFIQURRAKHMAN^¹, Chun WANG^¹, Michael BRYANT^¹(

)

1 Institute of Functional Surfaces, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom

2 Reliability Engineering Institute, National Engineering Research Center for Water Transport Safety, Wuhan University of Technology, Wuhan 430063, China

Keywords:

lubrication, polyethylene glycol, chemisorption, mucin, mucoadhesive

Cite this article:

HE X, SMART P, TAUFIQURRAKHMAN M, et al. Stable oral lubrication enhancer obtained from thiolated polyethylene glycol and mucin. Friction, 2023, 11(4): 617-634. https://doi.org/10.1007/s40544-022-0629-2

Download citation

EndNote(RIS)

BibTeX

412

Views

Downloads

Citations

Crossref

WoS

Scopus

CSCD

Abstract Full text Electronic supplementary material About this article

Abstract

Mucins are vital components contributing to the unique lubrication properties of human whole saliva. For patients receiving medication and or treatment such as diabetes or radiotherapy, xerostomia (dry mouth) is a common with numerous and deleterious side effects. Although products exist on the market to relive the symptoms of Xerostomia there remains a drive to formulate a biocompatible lubricant that replicate the functionality offered by the natural biological environment. Herein, a combination of mucin and thiolated polyethylene glycol (PEG-SH) was proposed as a new saliva substitute. Mucin and PEG-SH molecules could form hydrated layers immediately by chemisorption. Meanwhile, the chemical interactions between mucin and PEG-SH molecules also promoted the formation of a mixed layer. All the pre-formed layers could decrease friction and had the potential to decrease wear, especially mucin and PEG-SH mixed layer when compared to mucin only solutions. Further investigations of tribological mechanism implied that the excellent lubrication performance of mixed layer with long effectiveness was contributed to the friction-reducing effect of PEG/mucin molecules and the mucoadhesive property of mucin. The study provides a guide for using mucin as a mucoadhesive agent to stable lubricative polymers with low molecular weight as novel salivary substitutes for lubrication.

Full text

Abstract

Full text

Outline

Electronic supplementary material

About this article

Stable oral lubrication enhancer obtained from thiolated polyethylene glycol and mucin

Show Author's information Hide Author's Information Xiaoyan HE^{¹^,²}, Pravin SMART^¹, Mohamad TAUFIQURRAKHMAN^¹, Chun WANG^¹, Michael BRYANT^¹(

)

1 Institute of Functional Surfaces, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom

2 Reliability Engineering Institute, National Engineering Research Center for Water Transport Safety, Wuhan University of Technology, Wuhan 430063, China

Abstract

Keywords: lubrication, polyethylene glycol, chemisorption, mucin, mucoadhesive

References(38)

[1]

Wan H, Vissink A, Sharma P K. Enhancement in xerostomia patient salivary lubrication using a mucoadhesive. J Dent Res 99: 914–921 (2020)

DOI Google Scholar

[2]

Xu F, Laguna L, Sarkar A. Aging-related changes in quantity and quality of saliva: Where do we stand in our understanding? J Texture Stud 50: 27–35 (2019)

DOI Google Scholar

[3]

Vinke J, Kaper H J, Vissink A, Sharma P K. Dry mouth: Saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication. Clin Oral Invest 24: 4019–4030 (2020)

DOI Google Scholar

[4]

Wan H, Ma C, Vinke J, Vissink A, Herrmann A, Sharma P K. Next generation salivary lubrication enhancer derived from recombinant supercharged polypeptides for xerostomia. ACS Appl Mater Interfaces 12: 34524–34535 (2020)

DOI Google Scholar

[5]

Smart P, Neville A, Bryant M. Tribocorrosion of dental tissues: The role of mucin. Tribol Int 148: 106337 (2020)

DOI Google Scholar

[6]

Yakubov G E, Macakova L, Wilson S, Windust J H C, Stokes J R. Aqueous lubrication by fractionated salivary proteins: Synergistic interaction of mucin polymer brush with low molecular weight macromolecules. Tribol Int 89: 34–45 (2015)

DOI Google Scholar

[7]

Rondelli V, Cola E D, Koutsioubas A, Alongi J, Ferruti P, Ranucci E, Brocca P. Mucin thin layers: A model for mucus-covered tissues. Int J Mol Sci 20(15): 3712 (2019)

DOI Google Scholar

[8]

Castro I, Sepulveda D, Cortes J, Quest A F, Barrera M J, Bahamondes V, Aguilera S, Urzua U, Alliende C, Molina C, et al. Oral dryness in Sjogren's syndrome patients. Not just a question of water. Autoimmun rev 12: 567–574 (2013)

DOI Google Scholar

[9]

Zeng Q, Zheng L, Zhou J, Xiao H, Zheng J, Zhou Z. Effect of alcohol stimulation on salivary pellicle formation on human tooth enamel surface and its lubricating performance. J Mech Behav Biomed Mater 75: 567–573 (2017)

DOI Google Scholar

[10]

Song J, Lutz T M, Lang N, Lieleg O. Bioinspired dopamine/mucin coatings provide lubricity, wear protection, and cell-repellent properties for medical applications. Adv Healthc Mater 10: e2000831 (2021)

DOI Google Scholar

[11]

Marczynski M, Jiang K, Blakeley M, Srivastava V, Vilaplana F, Crouzier T, Lieleg O. Structural alterations of mucins are associated with losses in functionality. Biomacromolecules 22: 1600–1613 (2021)

DOI Google Scholar

[12]

Jiang K, Yan H, Rickert C, Marczynski M, Sixtensson K, Vilaplana F, Lieleg O, Crouzier T. Modulating the bioactivity of mucin hydrogels with crosslinking architecture. Adv Funct Mater 31: 2008428 (2021)

DOI Google Scholar

[13]

Petrou G, Crouzier T. Mucins as multifunctional building blocks of biomaterials. Biomater Sci 6: 2282–2297 (2018)

DOI Google Scholar

[14]

Shetty P, Mu L, Shi Y. Polyelectrolyte cellulose gel with PEG/water: Toward fully green lubricating grease. Carbohydr Polym 230: 115670 (2020)

DOI Google Scholar

[15]

Hu J, Andablo-Reyes E, Mighell A, Pavitt S, Sarkar A. Dry mouth diagnosis and saliva substitutes-A review from a textural perspective. J Texture Stud 52: 141–156 (2021)

DOI Google Scholar

[16]

Pailler-Mattei C, Vargiolu R, Tupin S, Zahouani H. Ex vivo approach to studying bio-adhesive and tribological properties of artificial salivas for oral dryness (xerostomia). Wear 332–333: 710–714 (2015)

DOI Google Scholar

[17]

Kane S R, Ashby P D, Pruitt L A. Characterization and tribology of PEG-like coatings on UHMWPE for total hip replacements. J Biomed Mater Res A 92: 1500–1509 (2010)

DOI Google Scholar

[18]

Han T, Yi S, Zhang C, Li J, Chen X, Luo J, Banquy X. Superlubrication obtained with mixtures of hydrated ions and polyethylene glycol solutions in the mixed and hydrodynamic lubrication regimes. J Colloid Interface Sci 579: 479–488 (2020)

DOI Google Scholar

[19]

Kobayashi M, Koide T, Hyon S H. Tribological characteristics of polyethylene glycol (PEG) as a lubricant for wear resistance of ultra-high-molecular-weight polyethylene (UHMWPE) in artificial knee join. J Mech Behav Biomed Mater 38: 33–38 (2014)

DOI Google Scholar

[20]

Sang T, Ye Z, Fischer N G, Skoe E P, Echeverria C, Wu J, Aparicio C. Physical-chemical interactions between dental materials surface, salivary pellicle and Streptococcus gordonii. Colloid Surf B 190: 110938 (2020)

DOI Google Scholar

[21]

Barrantes A, Arnebrant T, Lindh L. Characteristics of saliva films adsorbed onto different dental materials studied by QCM-D. Colloid Surf A 442: 56–62 (2014)

DOI Google Scholar

[22]

Yakubov G E, McColl J, Bongaerts J H H, Ramsden J J. Viscous boundary lubrication of hydrophobic surfaces by mucin. Langmuir 25: 2313–2321 (2009)

DOI Google Scholar

[23]

Oh S, Borros S. Mucoadhesion vs mucus permeability of thiolated chitosan polymers and their resulting nanoparticles using a quartz crystal microbalance with dissipation (QCM-D). Colloid Surf B 147: 434–441 (2016)

DOI Google Scholar

[24]

Xu F, Liamas E, Bryant M, Adedeji A F, Andablo‐Reyes E, Castronovo M, Ettelaie R, Charpentier T V J, Sarkar A. A self‐assembled binary protein model explains high‐performance salivary lubrication from macro to nanoscale. Adv Mater Interfaces 7: 1901549 (2019)

DOI Google Scholar

[25]

Clear S C, Nealey P F. Chemical force microscopy study of adhesion and friction between surfaces functionalized with self-assembled monolayers and immersed in solvents. J Colloid Interface Sci 213: 238–250 (1999)

DOI Google Scholar

[26]

Lee J. Nanoscopic friction behavior of pharmaceutical materials. Int J Pharm 340: 191–197 (2007)

DOI Google Scholar

[27]

Lanigan J L, Fatima S, Charpentier T V, Neville A, Dowson D, Bryant M. Lubricious ionic polymer brush functionalised silicone elastomer surfaces. Biotribology 16: 1–9 (2018)

DOI Google Scholar

[28]

Macakova L, Yakubov G E, Plunkett M A, Stokes J R. Influence of ionic strength changes on the structure of pre-adsorbed salivary films. A response of a natural multi-component layer. Colloid Surf B 77: 31–39 (2010)

DOI Google Scholar

[29]

Oh S, Wilcox M, Pearson J P, Borros S. Optimal design for studying mucoadhesive polymers interaction with gastric mucin using a quartz crystal microbalance with dissipation (QCM-D): Comparison of two different mucin origins. Eur J Pharm Biopharm 96: 477–483 (2015)

DOI Google Scholar

[30]

Simonin J-P. On the comparison of pseudo-first order and pseudo-second order rate laws in the modeling of adsorption kinetics. Chem Eng J 300: 254–263 (2016)

DOI Google Scholar

[31]

Alkan M, Demirbaş Ö, Doğan M, Arslan O. Surface properties of bovine serum albumin–adsorbed oxides: Adsorption, adsorption kinetics and electrokinetic properties. Micropor Mesopor Mater 96: 331–340 (2006)

DOI Google Scholar

[32]

Ho YS. Review of second-order models for adsorption systems. J Hazard Mater 136: 681–689 (2006)

DOI Google Scholar

[33]

Marczynski M, Balzer B N, Jiang K, Lutz T M, Crouzier T, Lieleg O. Charged glycan residues critically contribute to the adsorption and lubricity of mucins. Colloid Surf B 187: 110614 (2020)

DOI Google Scholar

[34]

Kitano H, Hayashi A, Takakura H, Suzuki H, Kanayama N, Saruwatari Y. Anti-biofouling properties of a telomer brush with pendent glucosylurea groups. Langmuir 25: 9361–9368 (2009)

DOI Google Scholar

[35]

He X, Liu Y, Bai X, Yuan C, Li H. Alginate/albumin in incubation solution mediates the adhesion and biofilm formation of typical marine bacteria and algae. Biochem Eng J 139: 25–32 (2018)

DOI Google Scholar

[36]

Sajewicz E. Effect of saliva viscosity on tribological behaviour of tooth enamel. Tribol Int 42: 327–332 (2009)

DOI Google Scholar

[37]

Klein J. Hydration lubrication. Friction 1: 1–23 (2013)

DOI Google Scholar

[38]

Information on https://bnf.nice.org.uk/clinical-medical-device-information-group/as-saliva-orthana-spray.html.

Electronic supplementary material

File

40544_0629_ESM.pdf (632.2 KB)

About this article

Publication history

Acknowledgements

Rights and permissions

Publication history

Received: 23 October 2021

Revised: 19 December 2021

Accepted: 01 April 2022

Published: 16 July 2022

Issue date: April 2023

Copyright

Acknowledgements

This work was supported by the International Postdoctoral Exchange Fellowship Program (Grant No. 20190060).

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.