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Friction 2023, 11(3): 410-424 https://doi.org/10.1007/s40544-022-0605-x
Research Article | Open Access | Issue | Published: 03 June 2022

Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release

Show Author's Information Qiangbing WEI1( ),  Tian FU1,2,  Lele LEI1,  Huan LIU1,2,  Yixin ZHANG1,  Shuanhong MA2,3( ),  Feng ZHOU2
Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
Shandong Laboratory of Yantai Advanced Materials and Green Manufacture, Yantai 264006, China
Keywords:
drug release, osteoarthritis treatment, functionalized nanoparticles, injectable biolubricant, friction reduction
Cite this article:
WEI Q, FU T, LEI L, et al. Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release. Friction, 2023, 11(3): 410-424. https://doi.org/10.1007/s40544-022-0605-x
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Abstract Full text About this article

Osteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA. Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required. Herein, dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt) (PDA–PSPMA) conjugate coating on hollow silica (h-SiO2) nanosphere surfaces to engineer functional nanoparticles (h-SiO2/PDA–PSPMA). The as-prepared h-SiO2/PDA–PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA–PSPMA coating and "rolling" effect of h-SiO2 nanospheres. In vitro drug loading-release experiments demonstrate that PDA–PSPMA coating functionalized h-SiO2 nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug, diclofenac sodium (DS). Such h-SiO2/PDA–PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication and drug release.


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About this article

Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release

Show Author's information Qiangbing WEI1( ), Tian FU1,2, Lele LEI1, Huan LIU1,2, Yixin ZHANG1, Shuanhong MA2,3( ), Feng ZHOU2
Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
Shandong Laboratory of Yantai Advanced Materials and Green Manufacture, Yantai 264006, China

Abstract

Osteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA. Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required. Herein, dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt) (PDA–PSPMA) conjugate coating on hollow silica (h-SiO2) nanosphere surfaces to engineer functional nanoparticles (h-SiO2/PDA–PSPMA). The as-prepared h-SiO2/PDA–PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA–PSPMA coating and "rolling" effect of h-SiO2 nanospheres. In vitro drug loading-release experiments demonstrate that PDA–PSPMA coating functionalized h-SiO2 nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug, diclofenac sodium (DS). Such h-SiO2/PDA–PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication and drug release.

Keywords: drug release, osteoarthritis treatment, functionalized nanoparticles, injectable biolubricant, friction reduction

References(55)

[1]
Stachowiak G, Batchelor A, Griffiths L. Friction and wear changes in synovial joints. Wear 171(1–2): 135–142 (1994)
DOI Google Scholar
[2]
Klein J. Molecular mechanisms of synovial joint lubrication. Proc Inst Mech Eng Part J J Eng Tribol 220(8): 691–710 (2006)
DOI Google Scholar
[3]
Jahn S, Seror J, Klein J. Lubrication of articular cartilage. Annu Rev Biomed Eng 18(1): 235–258 (2016)
DOI Google Scholar
[4]
Ji X, Zhang H. Current strategies for the treatment of early stage osteoarthritis. Front Mech Eng 5: 57 (2019)
DOI Google Scholar
[5]
Lin W, Klein J, Recent progress in cartilage lubrication. Adv Mater 33(18): 2005513 (2021)
DOI Google Scholar
[6]
Jean Y, Wen Z, Chang Y, Lee H, Hsieh S, Wu C, Yeh C, Wong C. Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament-transected knee: Association with excitatory amino acid release in the joint dialysate. J Orthop Soc 24(5): 1052–1061 (2006)
DOI Google Scholar
[7]
Vincent H K. Hyaluronic acid (HA) viscosupplementation on synovial fluid inflammation in knee osteoarthritis: A pilot study. Open Orthop J 7: 378–384 (2013)
DOI Google Scholar
[8]
Liu G, Liu Z, Li N, Wang X, Zhou F, Liu W. Hairy polyelectrolyte brushes-grafted thermosensitive microgels as artificial synovial fluid for simultaneous biomimetic lubrication and arthritis treatment. ACS Appl Mater Inter 6(22): 20452–20463 (2014)
DOI Google Scholar
[9]
Sun Y, Zhang H, Wang Y, Wang Y. Charged polymer brushes-coated mesoporous silica nanoparticles for osteoarthritis therapy: A combination between hydration lubrication and drug delivery. J Control Release 259: e45–e46 (2017)
DOI Google Scholar
[10]
Zhao W, Wang H, Wang H, Han Y, Zheng Z, Liu X, Feng B, Zhang H. Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis. Nanoscale 13(13): 6394–6399 (2021)
DOI Google Scholar
[11]
Zhang K, Yang J L, Sun Y L, Wang Y, Liang J, Luo J, Cui W G, Deng L F, Xu X Y, Wang B, Zhang H Y. Gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release. Friction 10(2): 232–246 (2022)
DOI Google Scholar
[12]
Klein J. Hydration lubrication. Friction 1(1): 1–23 (2013)
DOI Google Scholar
[13]
Jahn S, Klein J. Hydration lubrication: The macromolecular domain. Macromolecules 48(15): 5059–5075 (2015)
DOI Google Scholar
[14]
Coles J, Chang D. Molecular mechanisms of aqueous boundary lubrication by mucinous glycoproteins. Curr Opin Colloid Interface Sci 15(6): 406–416 (2010)
DOI Google Scholar
[15]
Dėdinaitė A. Biomimetic lubrication. Soft Matter 8(2): 273–284 (2012)
DOI Google Scholar
[16]
Adibnia V, Mirbagheri M, Faivre J, Robert J, Lee J, Matyjaszewski K, Lee D W, Banquy X. Bioinspired polymers for lubrication and wear resistance. Prog Polym Sci 110: 101298 (2020)
DOI Google Scholar
[17]
Zheng Y, Yang J, Liang J, Xu X, Cui W, Deng L, Zhang H. Bioinspired hyaluronic acid/phosphorylcholine polymer with enhanced lubrication and anti-inflammation. Biomacromolecules 20(11): 4135–4142 (2019)
DOI Google Scholar
[18]
Wei Q, Cai M, Zhou F, Liu W. Dramatically tuning friction using responsive polyelectrolyte brushes. Macromolecules 46(23): 9368–9379 (2013)
DOI Google Scholar
[19]
Chen M, Briscoe W H, Armes S P, Klein J. Lubrication at physiological pressures by polyzwitterionic brushes. Science 323(5922): 1698–1701 (2009)
DOI Google Scholar
[20]
Wei Q, Pei X, Hao J, Cai M, Zhou F, Liu W. Surface modification of diamond-like carbon film with polymer brushes using a bio-inspired catechol anchor for excellent biological lubrication. Adv Mater Interfaces 1(5): 1400035 (2014)
DOI Google Scholar
[21]
Gao L Y, Zhao X D, Ma S H, Ma Z F, Cai M R, Liang Y M, Zhou F. Constructing a biomimetic robust bi-layered hydrophilic lubrication coating on surface of silicone elastomer. Friction 10(7): 1032–1046 (2022)
DOI Google Scholar
[22]
Li Z, Ma S, Zhang G, Wang D, Zhou F. Soft/hard-coupled amphiphilic polymer nanospheres for water lubrication. ACS Appl Mater Interface 10(10): 9178–9187 (2018)
DOI Google Scholar
[23]
Lin W, Kampf N, Klein J. Designer nanoparticles as robust superlubrication vectors. ACS Nano 14(6): 7008–7017 (2020)
DOI Google Scholar
[24]
Zhao W, Wang H, Han Y, Wang H, Sun Y, Zhang H. Dopamine/phosphorylcholine copolymer as an efficient joint lubricant and ros scavenger for the treatment of osteoarthritis. ACS Appl Mater Interface 12(46): 51236–51248 (2020)
DOI Google Scholar
[25]
Wang C B, Bai X Q, Dong C L, Guo Z W, Yuan C Q, Neville A. Designing soft/hard double network hydrogel microsphere/UHMWPE composites to promote water lubrication performance. Friction 9(3): 551–568 (2021)
DOI Google Scholar
[26]
Yang J, Han Y, Lin J, Zhu Y, Wang F, Deng L, Zhang H, Xu X, Cui W. Ball-bearing-inspired polyampholyte-modified microspheres as bio-lubricants attenuate osteoarthritis. Small 16(44): 2004519 (2020)
DOI Google Scholar
[27]
Rahimi M, Charmi G, Matyjaszewski K, Banquy X, Pietrasik J. Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis. Acta Biomater 123: 31–50 (2021)
DOI Google Scholar
[28]
Han Y, Liu S, Sun Y, Gu Y, Zhang H. Bioinspired surface functionalization of titanium for enhanced lubrication and sustained drug release. Langmuir 35(20): 6735–6741 (2019)
DOI Google Scholar
[29]
Deng C, Zhang Q, Fu C, Zhou F, Yang W, Yi D, Wang X, Tang Y, Caruso F, Wang Y. Template-free synthesis of chemically asymmetric silica nanotubes for selective cargo loading and sustained drug release. Chem Mater 31(11): 4291–4298 (2019)
DOI Google Scholar
[30]
Manzano M, Vallet-Regí M. Mesoporous silica nanoparticles for drug delivery. Adv Funct Mater 30(2): 1902634 (2019)
DOI Google Scholar
[31]
Tan X, Sun Y, Sun T, Zhang H. Mechanised lubricating silica nanoparticles for on-command cargo release on simulated surfaces of joint cavities. Chem Commun 55(18): 2593–2596 (2019)
DOI Google Scholar
[32]
Liu G, Cai M, Zhou F, Liu W. Charged polymer brushes-grafted hollow silica nanoparticles as a novel promising material for simultaneous joint lubrication and treatment. J Phys Chem B 118(18): 4920–4931 (2014)
DOI Google Scholar
[33]
Yan Y, Sun T, Zhang H, Ji X, Sun Y, Zhao X, Deng L, Qi J, Cui W, Santos H A, Zhang H. Euryale ferox seed-inspired superlubricated nanoparticles for treatment of osteoarthritis. Adv Funct Mater 29(4): 1807559 (2019)
DOI Google Scholar
[34]
Chen H, Sun T, Yan Y, Ji X, Sun Y, Zhao X, Qi J, Cui W, Deng L, Zhang H. Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis. Biomaterials 242:119931 (2020)
DOI Google Scholar
[35]
Lee H, Dellatore S M, Miller W M, Messersmith P B. Mussel-inspired surface chemistry for multifunctional coatings. Science 318(5849): 426–430 (2007)
DOI Google Scholar
[36]
Sheng W, Li B, Wang X, Dai B, Yu B, Jia X, Zhou F. Brushing up from “anywhere” under sunlight: A universal surface-initiated polymerization from polydopamine-coated surfaces. Chem Sci 6(3): 2068–2073 (2015)
DOI Google Scholar
[37]
Ryu J H, Messersmith P B, Lee H. Polydopamine surface chemistry: A decade of discovery. ACS Appl Mater Interface 10(9): 7523–7540 (2018)
DOI Google Scholar
[38]
Behboodi-Sadabad F, Zhang H, Trouillet V, Welle A, Plumeré N, Levkin P A. UV-triggered polymerization, deposition, and patterning of plant phenolic compounds. Adv Funct Mater 27(22): 1700127 (2017)
DOI Google Scholar
[39]
He Y, Xu L, Feng X, Zhao Y, Chen L. Dopamine-induced nonionic polymer coatings for significantly enhancing separation and antifouling properties of polymer membranes: Codeposition versus sequential deposition. J Membrane Sci 529(1): 421–431 (2017)
DOI Google Scholar
[40]
Qiu W Z, Yang H C, Xu Z K. Dopamine-assisted co-deposition: An emerging and promising strategy for surface modification. Adv Colloid Interface 256: 111–125 (2018)
DOI Google Scholar
[41]
Zhang C, Ma M Q, Chen T T, Zhang H, Hu D F, Wu B H, Ji J, Xu Z K. Dopamine-triggered one-step polymerization and codeposition of acrylate monomers for functional coatings. ACS Appl Mater Interface 9(39): 34356–34366 (2017)
DOI Google Scholar
[42]
Wei Q, Liu X, Yue Q, Ma S, Zhou F. Mussel-inspired one-step fabrication of ultralow-friction coatings on diverse biomaterial surfaces. Langmuir 35(24): 8068–8075 (2019)
DOI Google Scholar
[43]
Ma M Q, Zhang C, Chen T T, Yang J, Wang J J, Ji J, Xu Z K. Bioinspired polydopamine/polyzwitterion coatings for underwater anti-oil and -freezing surfaces. Langmuir 35(5): 1895–1901 (2019)
DOI Google Scholar
[44]
Wang J, Tian J, Gao S, Shi W, Cui F. Dopamine triggered one step polymerization and codeposition of reactive surfactant on pes membrane surface for antifouling modification. Sep Purif Technol 249: 117148 (2020)
DOI Google Scholar
[45]
Zhu Z, Gao Q, Long Z, Huo Q, Ge Y, Vianney N, Daliko N A, Meng Y, Qu J, Chen H, et al. Polydopamine/ poly(sulfobetaine methacrylate) co-deposition coatings triggered by CuSO4/H2O2 on implants for improved surface hemocompatibility and antibacterial activity. Bioact Mater 6(8): 2546–2556 (2021)
DOI Google Scholar
[46]
Liu Q, Zhou Y, Li M, Zhao L, Ren J, Li D, Tan Z, Wang K, Li H, Hussain M, et al. Polyethylenimine hybrid thin-shell hollow mesoporous silica nanoparticles as vaccine self-adjuvants for cancer immunotherapy. ACS Appl Mater Interface 11(51): 47798–47809 (2019)
DOI Google Scholar
[47]
Zhang Y, Zhao Y, Cao S, Yin Z, Cheng L, Wu L. Design and synthesis of hierarchical SiO2@C/TiO2 hollow spheres for high-performance supercapacitors. ACS Appl Mater Interface 9(35): 29982–29991 (2017)
DOI Google Scholar
[48]
Qu Z, Yao L, Li J, He J, Mi J, Ma S, Tang S, Feng L. Bifunctional template-induced VO2@SiO2 dual-shelled hollow nanosphere-based coatings for smart windows. ACS Appl Mater Interface 11(17): 15960–15968 (2019)
DOI Google Scholar
[49]
Tiansong D, Frank M. Synthesis of monodisperse polystyrene@vinyl-SiO2 core–shell particles and hollow SiO2 spheres. Chem Mater 24(3): 536–542 (2012)
DOI Google Scholar
[50]
Li Z, Ma S, Zhang G, Wang D, Zhou F. Soft/hard-coupled amphiphilic polymer nanospheres for water lubrication. ACS Appl Mater Interface 10(10): 9178–9187 (2018)
DOI Google Scholar
[51]
Liu G, Wang D, Zhou F, Liu W. Electrostatic self-assembly of Au nanoparticles onto thermosensitive magnetic core–shell microgels for thermally tunable and magnetically recyclable catalysis. Small 11(23): 2807–2816 (2015)
DOI Google Scholar
[52]
Mei Y, Yu K, Lo J C Y, Takeuch L E, Hadjesfandiari N, Yazdani-Ahmadabadi H, Brooks D E, Lange D, Kizhakkedathu J N. Polymer–nanoparticle interaction as a design principle in the development of a durable ultrathin universal binary antibiofilm coating with long-term activity. ACS Nano 12(12): 11881–11891 (2018)
DOI Google Scholar
[53]
Tevet O, Von-Huth P, Popovitz-Biro R, Rosentsveig R, Wagner H D, Tenne R. Friction mechanism of individual multilayered nanoparticles. Proc Natl Acad Sci U S A 108(50): 19901–19906 (2011)
DOI Google Scholar
[54]
Ma L, Gaisinskaya-Kipnis A, Kampf N, Klein J. Origins of hydration lubrication. Nat Commun 6: 6060 (2015)
DOI Google Scholar
[55]
Tang F, Li L, Chen D. Mesoporous silica nanoparticles: Synthesis, biocompatibility and drug delivery. Adv Mater 24(12): 1504–1534 (2012)
DOI Google Scholar
Publication history
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Publication history

Received: 28 September 2021
Revised: 21 December 2021
Accepted: 31 January 2022
Published: 03 June 2022
Issue date: March 2023

Copyright

© The author(s) 2022.

Acknowledgements

This work was financially supported by National Natural Science Foundation of China (52065061, 22032006), Outstanding Youth Fund of Gansu Province (21JR7RA158, 21JR7RA095), Innovation Fund for Universities of Gansu Province (2021A-015), and Youth Innovation Promotion Association CAS (2019411).

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