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Friction 2022, 10(1): 128-141 https://doi.org/10.1007/s40544-020-0470-2
Research Article | Open Access | Issue | Published: 07 January 2021

A microfluidic bleeding model to investigate the effects of blood flow shear on microvascular hemostasis

Show Author's Information Xiangyu HU1,  Haosheng CHEN1,  Jiang LI2,  Kuilin MENG1,  Yuming WANG1,  Yongjian LI1( )
State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China
School of Mechanical Engineering, University of Science and Technology Beijing, Beijing 100083, China
Keywords:
microfluidic, hemostasis, platelet accumulation
Cite this article:
HU X, CHEN H, LI J, et al. A microfluidic bleeding model to investigate the effects of blood flow shear on microvascular hemostasis. Friction, 2022, 10(1): 128-141. https://doi.org/10.1007/s40544-020-0470-2
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Abstract Full text About this article

Hemorrhage is the phenomenon of blood loss caused by vascular trauma or other pathological reasons, which is life-threatening in severe cases. Because microhemorrhage is difficult to visually monitor and pre-treat in vivo, it is necessary to establish in vitro prediction methods to study the hemostasis mechanism in different physiological environments. In this study, a microfluidic bleeding model was developed to investigate the effect of blood flow shear on microvascular hemostasis. The results indicated that the regulation of blood shear rate on platelet aggregation affected the growth and morphology of hemostatic thrombus, and finally regulated the process of hemostasis. This in vitro model is significant to studies on hemostatic mechanisms, a reliable prediction of microhemorrhages, and an adjustment of the treatment scheme.


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About this article

A microfluidic bleeding model to investigate the effects of blood flow shear on microvascular hemostasis

Show Author's information Xiangyu HU1, Haosheng CHEN1, Jiang LI2, Kuilin MENG1, Yuming WANG1, Yongjian LI1( )
State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China
School of Mechanical Engineering, University of Science and Technology Beijing, Beijing 100083, China

Abstract

Hemorrhage is the phenomenon of blood loss caused by vascular trauma or other pathological reasons, which is life-threatening in severe cases. Because microhemorrhage is difficult to visually monitor and pre-treat in vivo, it is necessary to establish in vitro prediction methods to study the hemostasis mechanism in different physiological environments. In this study, a microfluidic bleeding model was developed to investigate the effect of blood flow shear on microvascular hemostasis. The results indicated that the regulation of blood shear rate on platelet aggregation affected the growth and morphology of hemostatic thrombus, and finally regulated the process of hemostasis. This in vitro model is significant to studies on hemostatic mechanisms, a reliable prediction of microhemorrhages, and an adjustment of the treatment scheme.

Keywords: microfluidic, hemostasis, platelet accumulation

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Publication history
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Publication history

Received: 22 July 2020
Revised: 22 October 2020
Accepted: 03 November 2020
Published: 07 January 2021
Issue date: January 2022

Copyright

© The author(s) 2020

Acknowledgements

This study was supported by the National Natural Science Foundation of China (No. 51875304) and the National Key R&D Program of China (No. 2018YFE0114900).

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