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Journal of Advanced Ceramics 2022, 11(4): 570-581 https://doi.org/10.1007/s40145-021-0557-z
Research Article | Open Access | Issue | Published: 03 March 2022

Preparation and properties of T-ZnOw enhanced BCP scaffolds with double-layer structure by digital light processing

Show Author's Information Ming-Zhu PANa,b,†,  Shuai-Bin HUAa,b,†,  Jia-Min WUa,b( ),  Xi YUANc,  Ze-Lin DENGa,b,  Jun XIAOc,  Yu-Sheng SHIa,b
State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education, Wuhan 430074, China
Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

† Ming-Zhu Pan and Shuai-Bin Hua contributed equally to this work.

Keywords:
digital light processing (DLP), biphasic calcium phosphate (BCP), T-ZnOw, double-layer structure, cure property, mechanical strength
Cite this article:
PAN M-Z, HUA S-B, WU J-M, et al. Preparation and properties of T-ZnOw enhanced BCP scaffolds with double-layer structure by digital light processing. Journal of Advanced Ceramics, 2022, 11(4): 570-581. https://doi.org/10.1007/s40145-021-0557-z
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Abstract Full text Electronic supplementary material About this article

Bone scaffolds require both good bioactivity and mechanical properties to keep shape and promote bone repair. In this work, T-ZnOw enhanced biphasic calcium phosphate (BCP) scaffolds with triply periodic minimal surface (TPMS)-based double-layer porous structure were fabricated by digital light processing (DLP) with high precision. Property of suspension was first discussed to obtain better printing quality. After sintering, T-ZnOw reacts with β-tricalcium phosphate (β-TCP) to form Ca19Zn2(PO4)14, and inhibits the phase transition to α-TCP. With the content of T-ZnOw increasing from 0 to 2 wt%, the flexural strength increases from 40.9 to 68.5 MPa because the four-needle whiskers can disperse stress, and have the effect of pulling out as well as fracture toughening. However, excessive whiskers will reduce the cure depth, and cause more printing defects, thus reducing the mechanical strength. Besides, T-ZnOw accelerates the deposition of apatite, and the sample with 2 wt% T-ZnOw shows the fastest mineralization rate. The good biocompatibility has been proved by cell proliferation test. Results confirmed that doping T-ZnOw can improve the mechanical strength of BCP scaffolds, and keep good biological property, which provides a new strategy for better bone repair.


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About this article

Preparation and properties of T-ZnOw enhanced BCP scaffolds with double-layer structure by digital light processing

Show Author's information Ming-Zhu PANa,b,†, Shuai-Bin HUAa,b,†, Jia-Min WUa,b( ), Xi YUANc, Ze-Lin DENGa,b, Jun XIAOc, Yu-Sheng SHIa,b
State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education, Wuhan 430074, China
Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

† Ming-Zhu Pan and Shuai-Bin Hua contributed equally to this work.

Abstract

Bone scaffolds require both good bioactivity and mechanical properties to keep shape and promote bone repair. In this work, T-ZnOw enhanced biphasic calcium phosphate (BCP) scaffolds with triply periodic minimal surface (TPMS)-based double-layer porous structure were fabricated by digital light processing (DLP) with high precision. Property of suspension was first discussed to obtain better printing quality. After sintering, T-ZnOw reacts with β-tricalcium phosphate (β-TCP) to form Ca19Zn2(PO4)14, and inhibits the phase transition to α-TCP. With the content of T-ZnOw increasing from 0 to 2 wt%, the flexural strength increases from 40.9 to 68.5 MPa because the four-needle whiskers can disperse stress, and have the effect of pulling out as well as fracture toughening. However, excessive whiskers will reduce the cure depth, and cause more printing defects, thus reducing the mechanical strength. Besides, T-ZnOw accelerates the deposition of apatite, and the sample with 2 wt% T-ZnOw shows the fastest mineralization rate. The good biocompatibility has been proved by cell proliferation test. Results confirmed that doping T-ZnOw can improve the mechanical strength of BCP scaffolds, and keep good biological property, which provides a new strategy for better bone repair.

Keywords: digital light processing (DLP), biphasic calcium phosphate (BCP), T-ZnOw, double-layer structure, cure property, mechanical strength

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Received: 11 August 2021
Revised: 09 November 2021
Accepted: 24 November 2021
Published: 03 March 2022
Issue date: April 2022

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© The Author(s) 2021.

Acknowledgements

This work was supported by the financial support from the Major Special Projects of Technological Innovation in Hubei Province (2019AAA002), the National Key R&D Program of China (2018YFB1105503), and Fundamental Research Funds for the Central Universities (2019kfyXMPY020, 2020kfyFPZX003, 2018KFYYXJJ030, and 2019kfyXKJC011). The authors would like to thank Chen-Min Yao and Xiao-Yi Wu from Hospital of Stomatology, Wuhan University for in vitro test, thank State Key Laboratory of Materials Processing and Die & Mould Technology for SEM and mechanical property tests, and also thank the Huazhong University of Science & Technology Analytical & Testing Center for XRD and FTIR tests.

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